Evidence map›Paper›PMID 41867240›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Intrinsic and extrinsic connectivity of the seizure onset zone at rest and during stimulation.

Joshua J LaRocque, William K S Ojemann, Jay Xu, Alfredo Lucas, Nishant Sinha, Eli J Cornblath, Caren Armstrong, Samuel Tomlinson, Eric Marsh, Saurabh R Sinha and 4 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Joshua J LaRocqueDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-3697-9965
William K S OjemannDepartment of Bioengineering, University of Pennsylvania.ORCID 0009-0007-5166-536X
Jay XuDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-4742-0665
Alfredo LucasDepartment of Bioengineering, University of Pennsylvania.ORCID 0000-0001-9439-735X
Nishant SinhaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-2090-4889
Eli J CornblathDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-2619-8778
Caren ArmstrongDepartment of Neurology, Children's Hospital of Philadelphia.ORCID 0000-0001-8010-0850
Samuel TomlinsonDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania.ORCID 0009-0005-4145-8530
Eric MarshDepartment of Neurology, Children's Hospital of Philadelphia.ORCID 0000-0003-3264-0902
Saurabh R SinhaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0003-0305-6731
Brian LittDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0003-2732-6927
Kathryn DavisDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-7020-6480
Quy CaoDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-6204-1305
Erin C ConradDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0001-8910-1817

Funding

Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Biomarkers to Predict Outcome from Responsive Brain Stimulation for EpilepsyR61NS125568 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVIS, KATHRYN ADAMIAK · 2023 to 2025
$3.6M
Optimized Intracranial EEG Targeting in Focal Epilepsy based upon Neuroimaging ConnectomicsR01NS116504 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DAVIS, KATHRYN ADAMIAK · 2021 to 2025
$3.3M
Guiding epilepsy surgery using network models and Stereo EEGR01NS125137 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2022 to 2025
$2.8M
Pennsieve: Impactful Multimodal Data Sharing for Epilepsy ResearchU24NS134536 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Joost B Wagenaar · 2024 to 2026
$2.6M
Quantitative interictal networks to localize seizure generatorsK23NS121401 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Erin Conrad · 2022 to 2026
$1.2M
Scalable methods to quantify epileptic network and guide epilepsy surgeryK99NS138680 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SINHA, NISHANT · 2024 to 2025
$298k
NINDS NIH HHS K23 NS121401NINDS NIH HHS K99 NS138680NINDS NIH HHS R01 NS116504NINDS NIH HHS R01 NS125137NINDS NIH HHS R61 NS125568NINDS NIH HHS T32 NS091006NINDS NIH HHS U24 NS134536
6 · The paper itself

Abstract

About half of patients who undergo epilepsy surgery for drug-resistant epilepsy have seizure recurrence, supporting the need for approaches that more accurately identify the

Identifiers

PMID41867240
PMCPMC13004088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.