Evidence map›Paper›PMID 41867179›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Temporal trends in

Rotha Eam, Kian Soon Hoon, Edwin Sutanto, Anjana Rai, Hidayat Trimarsanto, Angela Rumaseb, Sopheany Thin, Sreyneat Hor, Chhea Chhorvann, Tol Bunkea and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rotha EamMalaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.ORCID 0009-0003-6925-2919
Kian Soon HoonGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0000-0002-2310-3403
Edwin SutantoGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0000-0002-2997-4648
Anjana RaiGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0009-0005-9299-5715
Hidayat TrimarsantoGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0000-0003-2436-8283
Angela RumasebGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0000-0003-3939-0678
Sopheany ThinMalaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Sreyneat HorMalaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Chhea ChhorvannNational Institute of Public Health, School of Public Health, Phnom Penh, Cambodia.
Tol BunkeaNational Center for Malaria Control, Phnom Penh, Cambodia.
Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.
Jean PopoviciMalaria Research Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.ORCID 0000-0002-3135-1175
Sarah AuburnGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia.ORCID 0000-0002-4638-536X

Funding

Extent, dynamics and mechanisms of Plasmodium vivax immune evasion caused by PvDBP gene amplificationR01AI173171 · NIAID · INSTITUT PASTEUR DU CAMBODGE · PI Eugenia Lo, Jean POPOVICI · 2023 to 2026
$2.4M
Comprehensive characterization of the genetic factors and the host immune response associated to protection from clinical Plasmodium vivax malariaR01AI175134 · NIAID · INSTITUT PASTEUR DU CAMBODGE · PI TINEKE CANTAERT, Jean POPOVICI · 2023 to 2026
$2.3M
Leveraging access to parasite natural diversity to identify Plasmodium vivax culture-adaptable strain.R61AI187100 · NIAID · INSTITUT PASTEUR DU CAMBODGE · PI Jean POPOVICI · 2025 to 2026
$533k
NIAID NIH HHS R01 AI173171NIAID NIH HHS R01 AI175134NIAID NIH HHS R61 AI187100
6 · The paper itself

Abstract

Background: Elimination of Methods: Genotyping was conducted on 182 symptomatic Results: The genetic results correlated well with clinical case numbers for the study years. The percentage of polyclonal infections was 5% in 2023 compared to 22-48% in earlier years (p<0.05) suggesting substantial reduction in superinfection and aligning with accelerated primaquine use in 2021. The cases in 2023 also had the highest percentage of infections with IBD >0.95 with one or more other infections (81.4% versus 8.9-10.8% in 2014-2019) indicative of inbreeding following population bottlenecking. In 2019, there was a spike in polyclonal infections (48%) and population diversity following local interruption of critical malaria control services. Conclusions: Our findings illustrate the potential of microhaplotype genotyping to inform on

Indexed as

CambodiadiversitygenotypingMalariamicrohaplotypePlasmodium vivaxrelatednesstemporaltransmission

Identifiers

PMID41867179
PMCPMC13004073

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.