Evidence map›Paper›PMID 41867121›Full record

ReviewVirulence2026

Crosstalk between vimentin and keratins in viral infection: Implications across the viral life cycle.

Xiaolong Lu, Xiaoquan Wang, Xiufan Liu, Xiaowen Liu

Abstract readReview
In one paragraph

Review in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaolong LuKey Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Yangzhou University, Yangzhou, PR China.
Xiaoquan WangKey Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Yangzhou University, Yangzhou, PR China.
Xiufan LiuKey Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Yangzhou University, Yangzhou, PR China.ORCID 0000-0002-9924-6646
Xiaowen LiuKey Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, Yangzhou University, Yangzhou, PR China.ORCID 0009-0003-6802-5116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intermediate filaments (IFs) have long been regarded as a static scaffold responsible for maintaining cellular structure and integrity. However, recent studies have revealed that IFs, particularly vimentin and keratin, exert a profound and versatile influence on viral infection. In this narrative review, we summarize how these IFs influence multiple stages of the viral life cycle, including attachment/entry, replication, intracellular trafficking, assembly, and egress. We further discuss their contributions to cell-to-cell spread, host immune regulation, and oncogenic processes. Collectively, these findings illustrate how viruses exploit or remodel the IF network to facilitate propagation, and highlight IF - virus interfaces as potential targets for antiviral intervention.

Indexed as

KeratinsVimentinVirus DiseasesVirusesAnimalsHost-Pathogen InteractionsHumansIntermediate FilamentsVirus InternalizationVirus ReplicationKeratinsVimentinantiviral interventionIntermediate filamentskeratinvimentinviral infection

Identifiers

PMID41867121
PMCPMC13034636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.