Distribution of PEN-FAST scores across a large health system: an opportunity for penicillin-allergy delabeling.

backgroundPenicillin allergy reporting is common in U.S. healthcare systems, but true allergies and clinically significant reactions are inaccurately reported. Validated tools like PEN-FAST score allow for structured risk assessment; however, many clinicians remain unfamiliar with how to utilize the score to inform decision-making and prescribing. Integrating the PEN-FAST tool into the electronic health record (EHR) admission workflow may promote awareness and improve clinical utility.

methodsWe integrated the PEN-FAST tool into the admission navigator of our hospitals' electronic health record to be completed by nursing staff. Over a seven-month period, completed PEN-FAST scores across our health system were analyzed to evaluate the overall opportunity for allergy assessment and delabeling. The study population consisted of patients with a documented penicillin class allergy and a completed PEN-FAST score. Patients with incomplete scores or responses marked as unknown for every item were excluded.

resultsA total of 13,121 patients were included in the final evaluation. There were 10,309 (78.6%) patients with low-risk scores (PEN-FAST score of 0-2), indicating they were potential candidates for direct antibiotic challenges. The remaining 2,812 (21.4%) patients were categorized as high-risk (PEN-FAST score of 3+), who were likely not eligible for a challenge without prior skin testing.

conclusionA substantial opportunity remains to improve the assessment and documentation of penicillin allergies throughout the healthcare system. Utilizing the electronic health record to prompt frontline staff to use validated risk assessment tools may improve documentation of allergies and support better management of patients with penicillin allergy labels.