ArticleClinical and experimental dental research2026
Split-Mouth Comparison Between Autologous Dentin and Heterologous Bone in Bone Regeneration: Clinical Study on 15 Patients.
Article in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis study aims to compare the efficacy of heterologous bone grafts to autologous dentine-derived grafts (processed with the Tooth Transformer) in promoting bone regeneration in patients with posterior maxillary atrophy. MATERIALS AND
methodsA prospective, split-mouth study was performed on 15 patients (mean age 52 ± 8 years) with symmetrical post-extraction sites in the jaw. All patients received a heterologous bone graft on one side and an autologous dentine graft on the other. We evaluated new bone formation 4 months after surgery through histomorphometric analysis. Statistical analysis was carried out using paired t-tests and Wilcoxon tests, with a significance level of p < 0.05.
resultA histomorphometric evaluation revealed a significantly higher percentage of new bone formation in the sites treated with autologous dentine (mean 37.68%) compared to heterologous bone (mean 24.05%). The mean discrepancy between the groups was 13.63% (p < 0.001). Autologous dentine exhibited superior osteoinductive potential, attributable to the presence of bioactive molecules such as BMPs and Type I collagen, which were absent or denatured in heterologous bone. Both materials provided effective three-dimensional scaffolding, but dentine showed earlier osteoblastic colonization and enhanced biological activity at the grafting site.
conclusionAutologous dentine-derived grafts processed by the Tooth Transformer significantly outperform heterologous bone in terms of new bone formation in maxillary atrophy. The study highlights the potential of dentine as a promising regenerative biomaterial, offering a safe and effective solution tailored to individual patients, thereby reducing the need for additional donor sites or synthetic alternatives.
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