Evidence map›Paper›PMID 41867017›Full record

SynthesisHuman vaccines & immunotherapeutics2026

Influencing factors for severe pertussis among Chinese children: A meta-analysis.

Yingying Yang, Yaning Zhuo, Xinren Che, Wenwen Gu, Zhaojun Lu, Jun Wang, Yihan Hu, Jiarui Yu, Yan Liu

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingying YangDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.
Yaning ZhuoSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xinren CheDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.
Wenwen GuDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.
Zhaojun LuDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.
Jun WangDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.
Yihan HuSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jiarui YuSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yan LiuDepartment of Immunization Program, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou, Zhejiang, China.ORCID 0000-0002-7894-121X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study systematically evaluates factors influencing severe pertussis in Chinese children, providing scientific evidence for its prevention and treatment. A comprehensive search of PubMed, Embase, Web of Science, CNKI, and Wanfang identified literature on factors influencing severe pertussis in Chinese children up to September 30, 2025. We conducted a meta-analysis, and data were combined using either fixed or random models. A total of 24 studies included 839 severe pertussis cases and 4,280 non-severe cases. Severe pertussis was significantly associated with several factors, with the top five strongest associations being: lung consolidation or atelectasis (OR: 15.44; 95%CI: 9.06-26.31), three concave sign (OR: 12.91; 95%CI: 5.46-30.53), elevated C-reactive protein (OR: 5.33; 95%CI: 3.00-9.49), unvaccinated with DTP vaccine (OR: 4.00; 95%CI: 2.86-5.58), and white blood cell count (WMD: 16.42 × 10

Indexed as

Whooping CoughChildChild, PreschoolChinaC-Reactive ProteinEast Asian PeopleHumansInfantRisk FactorsSeverity of Illness IndexUnvaccinated PersonsC-Reactive ProteinchildrenChinainfluencing factormeta-analysisSevere pertussis

Identifiers

PMID41867017
PMCPMC13011614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.