Evidence map›Paper›PMID 41866913›Full record

ArticleAmerican journal of primatology2026

A Collaborative, Multi-Institutional Growth Standard for Dam-Reared Infant Rhesus and Pigtail Macaques (Macaca mulatta and Macaca nemestrina) in Research Settings.

Andrew J Haertel, Kathryn E Berns, Kathrine Shelley P Falkenstein, Axelle Kamanzi Shimwa, Charlotte Hotchkiss, Lydia M Hopper, Leanne Gill, Brian Spray, Elizabeth Maldonado, Maria M Crane and 24 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Andrew J HaertelOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0002-1090-8253
Kathryn E BernsOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0009-0007-2951-4370
Kathrine Shelley P FalkensteinDepartment of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana, USA.
Axelle Kamanzi ShimwaDepartment of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana, USA.
Charlotte HotchkissAnimal Resources Division, Washington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Lydia M HopperDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5953-3264
Leanne GillCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Brian SprayCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Elizabeth MaldonadoCaribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
Maria M CraneDivision of Developmental and Cognitive Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Grace H LeeAnimal Resources Division, Washington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Kelsey E CarrollCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Diane E StockingerCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Jeffrey A RobertsCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Lauren C CassidyCalifornia National Primate Research Center, University of California Davis, Davis, California, USA.
Melissa NegronCaribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
Angelina V Ruiz LambidesCaribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
Brianne A BeisnerDivision of Developmental and Cognitive Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Jacklyn RamseyDivision of Animal Resources, Emory National Primate Research Center Field Station, Emory University, Lawrenceville, Georgia, USA.
Joyce K CohenDivision of Animal Resources, Emory National Primate Research Center Field Station, Emory University, Lawrenceville, Georgia, USA.
Fawn Connor-StroudDivision of Animal Resources, Emory National Primate Research Center Field Station, Emory University, Lawrenceville, Georgia, USA.
Joshua M TaylorOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.
Erika Wright-McAfeeSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Stanton GraySouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
John Jack DuttonSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Kenneth SayersSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Travis ChurchSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Kathy BraskySouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Cathy TsagournosDepartment of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana, USA.
Sylvain NyandwiDepartment of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana, USA.
Adam MyersDepartment of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana, USA.ORCID 0009-0002-7151-7229
Jeana BarrowAnimal Resources Division, Washington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Lina GaoBioinformatics & Biostatistics Core, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0001-9382-0419
L Drew MartinOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Viral TestingU42OD021458 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2016 to 2026
$45.1M
Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal · 2012 to 2026
$35.6M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI Melissa R Berg, Cindy Buckmaster · 2012 to 2026
$34.4M
Viral Testing CoreU42OD024282 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2017 to 2026
$25.7M
Viral Testing Core - Maintenance of an SPF Macaque Breeding Colony for AIDS ResearchU42OD010568 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2013 to 2026
$21.7M
NIH HHS P40 OD012217NIH HHS P51 OD010425NIH HHS P51 OD011092NIH HHS P51 OD011104NIH HHS P51 OD011107NIH HHS P51 OD011132NIH HHS P51 OD011133NIH HHS U42 OD010426NIH HHS U42 OD010442NIH HHS U42 OD010568NIH HHS U42 OD010990NIH HHS U42 OD011023NIH HHS U42 OD011123NIH HHS U42 OD013117NIH HHS U42 OD021458NIH HHS U42 OD024282ODCDC CDC HHS P51 OD011092ODCDC CDC HHS P51 OD011104ODCDC CDC HHS U42 OD010426ODCDC CDC HHS U42 OD010568ODCDC CDC HHS U42 OD024282Office of Research Infrastructure Programs, National Institutes of Health 5U42OD013117-17Office of Research Infrastructure Programs, National Institutes of Health P51OD010425Office of Research Infrastructure Programs, National Institutes of Health P51OD011107Office of Research Infrastructure Programs, National Institutes of Health P51OD011132Office of Research Infrastructure Programs, National Institutes of Health P51OD011133Office of Research Infrastructure Programs, National Institutes of Health U42OD010442Office of Research Infrastructure Programs, National Institutes of Health U42OD010990Office of Research Infrastructure Programs, National Institutes of Health U42OD011023Office of Research Infrastructure Programs, National Institutes of Health U42OD011123Office of Research Infrastructure Programs, National Institutes of Health U42OD021458
6 · The paper itself

Abstract

A multicenter study was undertaken to generate new weight-for-age growth standards to monitor the growth of infant rhesus and pigtail macaques in research breeding colonies. Previously, single institutions have developed reference growth curves, under the assumption of linear growth, for infants raised in certain settings with a limited scope of benefit to outside institutions. Weight and health records from seven research institutions across the USA were used to build models of body weight by age. Linear and Box-Cox Power Exponential (BCPE) distribution models, which have been adopted from the World Health Organization's methods, were compared to find the best fit of the models. Resultant weight percentiles and growth velocity charts were provided from the best-fit model ranked by generalized Akaike's information criterion. Multiparameter models with the BCPE distribution fit the data better than linear models with normal distributions. The assumption that infant macaque growth is linear was challenged by our findings; growth rates appear to change over the first year of life for infant macaques. Growth standards were integrated into centile charts and a computer application in MS Excel to provide user-friendly weight-for-age percentile charts to access and analyze macaque growth data. The new growth standards provide a unified reference that best represents normal physiological growth for all infant rhesus and pigtail macaques from birth through the first year of life. These standards offer guidance on expected growth trajectories and serve as a benchmark for assessing the healthy development of macaque infants across research breeding colonies.

Indexed as

Growth ChartsMacaca mulattaMacaca nemestrinaAnimalsBody WeightFemaleMaleReference ValuesBox‐Cox Power Exponential distributioncaptive managementGAMLSSnonhuman primatepercentiles

Identifiers

PMID41866913
PMCPMC13041731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.