ArticleCroatian medical journal2026
Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats.
Article in Croatian medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess whether a cranial defect in anesthetized cats alters cerebrospinal fluid (CSF) pressure distribution across the craniospinal axis in different body positions in the setting of intracranial normotension.
methodsAfter standardized parietal craniectomy, intracranial and lumbar CSF pressures were simultaneously measured in eight adult anesthetized (?-chloralose, i.p. 100 mg/kg) cats in different body positions: horizontal (0°), head-up (45°; 90°), and head-down (225°; 270°). CSF pressure gradient represents the difference between CSF pressure values in the lateral ventricle (LV) and lumbar subarachnoid space (LSS) in each body position.
resultsAt 0°, CSF pressures in the LV and LSS were similar (16.2±0.9 vs 15.8±1.2 cm H2O, respectively). In the 90° head-up position, LV pressure was subatmospheric (?1.5±0.5 cm H2O), while LSS pressure simultaneously increased (31.4±1.0 cm H2O). Conversely, in the head-down 270° position, LSS pressure was negative (?1.7±1.5 cm H2O) and LV pressure increased (30.0?±?1.8 cm H2O). Difference between LV and LSS pressures is strongly correlated with hydrostatic difference between the two recording points in the head-up and the head-down position. LV pressure at 90° in the craniectomy group was significantly higher than previously published in cats with an intact cranium in the same position (P<0.001).
conclusionHydrostatic CSF pressure gradient across the craniospinal axis remained unaltered by craniectomy. The finding that craniectomy in the head-up position of animals without intracranial pathology resulted in an intracranial pressure increase may offer additional explanation for the trephined syndrome pathophysiology.
Indexed as
Identifiers
41866898PMC13014296What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.