Evidence map›Paper›PMID 41866852›Full record

ArticleJournal of the American Chemical Society2026

High-Affinity Six-Letter DNA XenoAptamer Generation by Genetic Alphabet Expansion.

Ken-Ichiro Matsunaga, Hui Pen Tan, Joo Leng Low, Michiko Kimoto, Ichiro Hirao

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ken-Ichiro MatsunagaXenolis Pte. Ltd., 85 Science Park Drive, #02-08, The Cavendish, Singapore 118259, Singapore.
Hui Pen TanXenolis Pte. Ltd., 85 Science Park Drive, #02-08, The Cavendish, Singapore 118259, Singapore.ORCID 0009-0001-7342-3405
Joo Leng LowXenolis Pte. Ltd., 85 Science Park Drive, #02-08, The Cavendish, Singapore 118259, Singapore.
Michiko KimotoXenolis Pte. Ltd., 85 Science Park Drive, #02-08, The Cavendish, Singapore 118259, Singapore.ORCID 0000-0002-6261-7562
Ichiro HiraoXenolis Pte. Ltd., 85 Science Park Drive, #02-08, The Cavendish, Singapore 118259, Singapore.ORCID 0000-0002-1115-8079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A method for generating high-affinity DNA aptamers (XenoAptamers) that bind to target proteins with a dissociation constant (

Indexed as

Aptamers, NucleotideDNAInterleukin-8ThrombinEnzyme-Linked Immunosorbent AssayHumansAptamers, NucleotideDNAInterleukin-8Thrombin

Identifiers

PMID41866852
PMCPMC13067341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.