Evidence map›Paper›PMID 41866802›Full record

ArticlePhysiological reports2026

Stroke increases motor output variability during maximal voluntary isometric contractions of knee extensor muscles in adults.

Zhilun Zhou, Stephanie C Wolfe, Brian D Schmit, Matthew J Durand, Sandra K Hunter, Allison S Hyngstrom

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhilun ZhouDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin, USA.
Stephanie C WolfeDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin, USA.
Brian D SchmitJoint Department of Biomedical Engineering, Marquette University & Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew J DurandDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Sandra K HunterSchool of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-8013-2051
Allison S HyngstromDepartment of Physical Therapy, Marquette University, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0000-0003-1798-0722

Funding

Ischemic Conditioning and Improved Motor Function Post StrokeR01HD099340 · NICHD · MARQUETTE UNIVERSITY · PI DURAND, MATTHEW, HYNGSTROM, ALLISON SUZANNE · 2019 to 2023
$2.1M
Sex-Specific Impact of Stroke on Neuromuscular Fatigability in Older AdultsK00AG083283 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Zhilun Zhou · 2025 to 2026
$170k
Sex-Specific Impact of Stroke on Neuromuscular Fatigability in Older AdultsF99AG083283 · NIA · MARQUETTE UNIVERSITY · PI ZHOU, ZHILUN · 2023 to 2023
$36k
American Heart Association (AHA) 903373HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD099340HHS | NIH | National Institute on Aging (NIA) F99AG083283HHS | NIH | National Institute on Aging (NIA) K00AG083283NIA NIH HHS F99 AG083283NIA NIH HHS K00 AG083283NICHD NIH HHS R01 HD099340
6 · The paper itself

Abstract

Greater motor output variability (MOV, inconsistency and unsteadiness) during submaximal tasks post stroke is associated with poorer motor performance. However, little is known about MOV during maximal tasks and relationships with clinical measures of motor performance among stroke survivors. This study determined inconsistency (across discrete attempts) and unsteadiness (within a single attempt) during knee extension maximal voluntary isometric contractions (MVICs) in stroke survivors and neurotypical controls. Forty-three stroke survivors (28 female) and 31 age-matched neurotypical controls (15 female) performed a minimum of five knee extension MVICs with paretic and non-paretic legs (stroke) or dominant leg (controls). Inconsistency was calculated as coefficient of variation between maximal torque values of each MVIC. Unsteadiness was calculated as the average from coefficient of variation of the torque values during each MVIC. The paretic leg of stroke survivors had greater MVIC inconsistency (7.61 ± 4.31% vs. 4.94 ± 2.77%, p = 0.014) and unsteadiness (7.00 ± 3.16% vs. 3.44 ± 1.68%, p < 0.001) than the dominant leg of neurotypical controls. Greater MVIC inconsistency (r

Indexed as

Isometric ContractionKneeMuscle, SkeletalStrokeAdultAgedFemaleHumansMaleMiddle AgedParesisTorqueinconsistencyknee extensorsmotor output variabilitystrokeunsteadiness

Identifiers

PMID41866802
PMCPMC13098027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.