ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2026
The Bioactive Side of Peas: Bio-functional Potential of Pea-Derived Ingredients on Cardiovascular Health.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Rethinking Plant Proteins: Innovations in Nutrition, Processing, and Food Development.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
Legumes are important sources of high-value ingredients for the development of healthy foods. This study evaluated biological activities related to cardiovascular health -namely antioxidant, antihypertensive, and antithrombotic- associated with peptides from three yellow pea–derived ingredients: flour (F), protein isolate (I), and naturally fermented flour (FF; flour/water 14.3%, w/w, 24 h, 37 °C). Ingredients were subjected to in vitro simulated gastrointestinal digestion. Soluble digests (FDd, IDd, FFDd) were recovered and further treated with cholestyramine to reduce bile salts (bioaccessible fractions: FDb, IDb, FFDb). Degrees of proteolysis reached 37, 36, and 53% (ID, FD, FFD, respectively), indicating that fermentation enhanced protein digestion. Digests exhibited high protein solubility, and a predominance of < 6.5 kDa peptides with differences between samples. Cholestyramine treatment reduced soluble protein content. Bioaccessible fractions showed low cytotoxicity and effectively reduced reactive oxygen species in Caco-2 TC7 cells (IC50: 0.38, 0.62, 0.28 mg protein/mL for IDb, FDb, and FFDb, respectively), with FFDb displaying the strongest intracellular antioxidant activity. Antithrombotic effects were dose-dependent in digests (IC50: 2.1, 2.5, 3.1 mg/mL for IDd, FDd, and FFDd, respectively) but absent in bioaccessible fractions. All digests inhibited angiotensin-converting enzyme (IC50: 1.7, 2.0, 1.2 mg/mL for IDd, FDd, and FFDd, respectively), with bioaccessible fractions showing greater potency (1.25, 0.412, and 0.534 mg/mL). Consistently, in silico gastrointestinal digestion of major pea proteins indicated the presence of digestion-derived peptide pools associated with cardiovascular health–related functions. Overall, peptides released from pea proteins may contribute to the potential prevention of cardiovascular diseases. Fermentation improved digestibility, antioxidant and ACE inhibitory activities.
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Identifiers
41866635What OpenQuestion holds
Registered trials
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