Evidence map›Paper›PMID 41866632›Full record

ArticleThe Journal of antibiotics2026

New antimalarial dimeric diketopiperazines, piperasagamines A and B, produced by a deep-sea-derived fungus Aspergillus sp. FKJ-0404 strain.

Karin Hamada, Yoshihiro Watanabe, Hiroki Kojima, Toshiyuki Tokiwa, Mayuka Higo, Akihiro Sugawara, Kenichi Nonaka, Tomoyasu Hirose, Yuriko Nagano, Rei Hokari and 2 more

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karin Hamada *Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Yoshihiro Watanabe *Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-5756-0530
Hiroki KojimaGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Toshiyuki TokiwaŌmura Satoshi Memorial Institute, Kitasato University, Minato-ku, Tokyo, Japan.
Mayuka HigoGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Akihiro SugawaraGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1266-7497
Kenichi NonakaGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Tomoyasu HiroseGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9463-8181
Yuriko NaganoDeep-Sea Biodiversity Research Group, Marine Biodiversity and Environmental Assessment Research Center, Japan Agency for Marine-Earth Science and Technology, Yokosuka, Kanagawa, Japan.
Rei HokariGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Aki IshiyamaGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0003-4703-8834
Masato IwatsukiGraduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan. iwatuki@lisci.kitasato-u.ac.jp.ORCID http://orcid.org/0000-0001-8373-4314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new dimeric diketopiperazines, piperasagamines A (1) and B (2), were discovered from the cultured material of a deep-sea-derived Aspergillus sp. FKJ-0404 strain. The planar structures of 1 and 2 were elucidated by spectroscopic analysis as dimeric diketopiperazines featuring an α, β-dehydroproline moiety. The absolute configurations of 1 and 2 were determined by advanced Marfey's analysis combined with the analysis of their reduced derivatives. Among them, 2 showed moderate antimalarial activity with an IC

Indexed as

AntimalarialsAspergillusDiketopiperazinesInhibitory Concentration 50Magnetic Resonance SpectroscopyMolecular StructurePlasmodium falciparumAntimalarialsDiketopiperazines

Identifiers

PMID41866632

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.