ArticleJournal of medical case reports2026
Complete NUB1 depletion in ER - negative breast cancer progression in paired primary-metastatic cases: a case series.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNEDD8 ultimate buster 1 is an interferon-inducible tumor suppressor increasingly recognized as a prognostic biomarker in breast cancer. Low cytoplasmic expression correlates with aggressive disease, yet little is known about its dynamics between primary and metastatic estrogen-receptor-negative tumors.
objectiveThe objective of this report is to compare NEDD8 ultimate buster 1 expression in paired estrogen-receptor-negative primary and metastatic breast cancer tissues, clarifying its role in tumor progression. CASE PRESENTATION: Two postmenopausal Caucasian women, patient A (ID: 14,024, aged 58 years) and patient B (ID: 20,996, aged 54 years), both diagnosed with estrogen-receptor-negative, human epidermal growth factor receptor 2-negative, grade III invasive ductal carcinoma, underwent NEDD8 ultimate buster 1 immunohistochemical analysis on matched primary breast tumors and corresponding metastatic lymph nodes. Both primary tumors exhibited high nuclear but low cytoplasmic NEDD8 ultimate buster 1, shifting to complete loss in metastases. The patient with higher primary cytoplasmic NEDD8 ultimate buster 1 had longer relapse-free and overall survival.
conclusionLoss of NEDD8 ultimate buster 1 in metastases may signal a transition from hypoxia-driven nuclear localization to unchecked metastatic progression. These findings highlight NEDD8 ultimate buster 1 as a potential prognostic marker and therapeutic stratifier, warranting larger studies to confirm its mechanistic and clinical relevance.
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