Evidence map›Paper›PMID 41866551›Full record

ReviewCell & bioscience2026

The role of stem cells and their engineering strategies in the repair of nerve damage in intracerebral hemorrhage.

Liangzhe Wei, He Ren, Yuanwei Lin, Jie Sun, Sheng Nie, Xiang Gao, Yi Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liangzhe WeiNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China.
He RenNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China.
Yuanwei LinDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China.
Jie SunNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China.
Sheng NieNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China.
Xiang GaoNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China. fyygaoxiang@nbu.edu.cn.
Yi HuangNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China. huangy102@gmail.com.ORCID http://orcid.org/0000-0003-3598-9747

Funding

Chronic Disease Management Research Project of National Health Commission Capacity Building and Continuing Education Center GWJJMB202510021112Ningbo Clinical Research Center for Emergency and Critical Diseases 2024L003Ningbo Natural Science Foundation 2023J019Ningbo Top Medical and Health Research Program 2022020304Ningbo Youth Science and Technology Innovation Leading Talent Project 2025QL015Zhejiang Provincial Natural Science Foundation LMS26H090007
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a devastating neurological condition with high mortality and morbidity. Despite advancements in medical and surgical treatments, the long-term prognosis of ICH remains poor. Stem cell therapy emerges as a promising therapeutic strategy, offering potential benefits in neuroprotection and neuroregeneration. Preclinical studies have demonstrated the efficacy of stem cell therapy in reducing brain injury and improving neurological function after ICH. In particular, the application and mechanisms of engineered stem cells in neural repair following ICH warrant further investigation. Through strategies such as pre-processing, gene editing, biomaterial modification, and extracellular vesicle engineering, engineered stem cells have demonstrated significant advantages in enhancing cell survival, immune regulation, and neural regeneration. This article also provides an overview of the latest developments in neuroprotective drug treatment strategies, pointing out that future research should focus on the synergistic effects of engineered stem cells and host microenvironment, promoting the development of precision and clinical translation of ICH treatment.

Indexed as

Brain injuryClinical researchExosomesIntracerebral hemorrhageMechanismNeural damageNeuroprotectionNeuroregenerationPathophysiologyStem cell transplantation

Identifiers

PMID41866551
PMCPMC13491715

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.