Evidence map›Paper›PMID 41866508›Full record

ArticleJournal of medical case reports2026

Diode-laser-assisted biopsy and photobiomodulation therapy in the management of Sjögren's disease: a case report.

Carlos Sanchez-Ramirez, Ana Luisa Bernotti, Erica De Jesús, Alberto Miselli, Gredy Lugo, Mariana Villarroel-Dorrego

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos Sanchez-RamirezFaculty of Dentistry, Central University of Venezuela, Los Chaguaramos, Caracas, 1050, Venezuela. odcarlossanchez@gmail.com.ORCID http://orcid.org/0000-0002-6098-5839
Ana Luisa BernottiFaculty of Dentistry, Central University of Venezuela, Los Chaguaramos, Caracas, 1050, Venezuela.ORCID http://orcid.org/0009-0001-2480-886X
Erica De JesúsFaculty of Dentistry, José Antonio Páez University, Valencia, Carabobo, Venezuela.ORCID http://orcid.org/0009-0004-5413-0027
Alberto MiselliFaculty of Dentistry, CEYESOV University, Veracruz, México.ORCID http://orcid.org/0000-0002-2992-2872
Gredy LugoFaculty of Dentistry, Central University of Venezuela, Los Chaguaramos, Caracas, 1050, Venezuela.ORCID http://orcid.org/0009-0002-5808-7383
Mariana Villarroel-DorregoFaculty of Dentistry, Central University of Venezuela, Los Chaguaramos, Caracas, 1050, Venezuela.ORCID http://orcid.org/0000-0002-0596-1527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSjögren's disease is a systemic autoimmune disease characterized by dysfunction of the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. CASE PRESENTATION: A 55-year-old Hispanic female patient was diagnosed following a minor salivary gland biopsy performed using a diode laser. Wound healing was successfully managed through local photobiomodulation therapy combined with topical application of an active oxygen-lactoferrin gel and mouthwash (Blue

conclusionThis case highlights the use of laser for safe biopsy of minor salivary glands in Sjögren's disease and the potential of intraoral and extraoral photobiomodulation therapy, including lymphatic node stimulation, combined with active oxygen-lactoferrin-based oral care as an effective adjunctive protocol for the clinical treatment of Sjögren's disease.

Indexed as

Lasers, SemiconductorLow-Level Light TherapySalivary Glands, MinorSjogren's SyndromeBiopsyCombined Modality TherapyFemaleHumansLactoferrinMiddle AgedTreatment OutcomeXerophthalmiaXerostomiaLactoferrinActive oxygenDiode laserLactoferrinPhotobiomodulationSjögren’s diseaseSjögren’s syndromeXerostomia

Identifiers

PMID41866508
PMCPMC13130530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.