Evidence map›Paper›PMID 41866502›Full record

ArticleBiomedical engineering online2026

Compliance-mediated pressure-independent cerebrovascular regulation: a distinct novel mechanism in youth.

Zijie Wang, Youjun Liu, Hao Sun, Tengfei Li, Liyuan Zhang, Guangfei Li, Binxu Yang, Yanjun Gong, Bao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zijie WangDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Youjun LiuDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Hao SunDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Tengfei LiDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Liyuan ZhangDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Guangfei LiDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Binxu YangDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Yanjun GongDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Bao LiDepartment of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, No. 100 Pingleyuan, Chaoyang District, Beijing, 100124, China. libao@bjut.edu.cn.

Funding

the Beijing Natural Science Foundation 4242032the National Foreign Experts Program H20250719the National Key Research and Development Program of China 2021YFA1000202the National Natural Science Foundation of China 12202022the National Natural Science Foundation of China 12572064the National Natural Science Foundation of China 32271361
6 · The paper itself

Abstract

Cerebrovascular regulatory capacity is essential for maintaining brain stability. Most previous studies have focused on middle-aged and elderly populations, where regulation depends on vasodilation with reduced resistance and elevated blood pressure-the pressure-dependent mechanism. Whether this paradigm applies to younger individuals remains unclear. Given the rising prevalence of cardiovascular and cerebrovascular risks in young adults, elucidating youth-specific mechanisms is of great importance. In this study, standardized breath-holding was used to induce hypercapnia in 52 young volunteers (23.67 ± 1.77 years). Hemodynamic parameters of both middle cerebral arteries (blood pressure, heart rate, and flow velocity) were measured at rest and during hypercapnia. The breath-holding index (BHI), reflecting cerebrovascular regulatory capacity, was calculated, and a hemodynamic model was applied to derive resistance variation coefficient (

Indexed as

Blood PressureCerebrovascular CirculationAdultBreath HoldingComplianceFemaleHeart RateHemodynamicsHumansHypercapniaMaleMiddle Cerebral ArteryYoung AdultBreath-holding experimentBreath-holding index (BHI)Cerebral blood flow regulationCerebrovascular complianceHypercapnia

Identifiers

PMID41866502
PMCPMC13130797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.