ArticleBMC nephrology2026
Erythrodermic psoriasis complicated by immune complex-mediated crescentic glomerulonephritis and atypical hemolytic uremic syndrome: a case report.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundErythrodermic psoriasis (EP) is a severe, systemic inflammatory dermatosis. While kidney involvement is rare, the massive cytokine release associated with EP can induce systemic complications. We report a rare case of EP complicated by the simultaneous onset of immune complex-mediated crescentic glomerulonephritis (GN) and atypical haemolytic uraemic syndrome (aHUS), highlighting a severe form of complement-mediated renal injury in the context of dermatological inflammation. CASE PRESENTATION: A 52-year-old male presented with a three-month history of diffuse erythrodermic psoriasis following herbal supplement ingestion, complicated by progressive anasarca and acute kidney injury. Laboratory findings showed nephrotic-range proteinuria, microscopic haematuria, thrombocytopaenia (platelets 41 × 10^9/L), microangiopathic haemolysis (elevated lactate dehydrogenase and schistocytes), and low complement C3 levels. Skin biopsy confirmed EP. Renal biopsy revealed diffuse endocapillary proliferation and crescent formation (20% of glomeruli) with immune complex deposition (granularIgG, IgA), alongside features of thrombotic microangiopathy (endothelial swelling, segmental double contours). The patient was successfully treated with corticosteroids, intravenous immunoglobulin, and the terminal complement inhibitor eculizumab, resulting in normalisation of haematological parameters and substantial renal recovery.
conclusionsThis case underscores a critical pathogenic link between severe psoriasis-associated systemic inflammation, immune complex deposition, and complement-mediated microangiopathy. Early recognition of this overlap syndrome and prompt complement inhibition are crucial for preventing irreversible kidney disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.