Trial reportEuropean journal of pediatrics2026
Impact of a nurse-driven high-flow nasal cannula weaning protocol on HFNC duration in infants with bronchiolitis: a randomized controlled trial.
Trial report in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06621641 (Outcomes of a Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Critical Bronchiolitis Patients), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of a Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Critical Bronchiolitis Patients
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate whether a nurse-driven high-flow nasal cannula (HFNC) weaning protocol reduces HFNC duration and hospitalization in infants with severe bronchiolitis. This prospective, randomized controlled study was conducted in two tertiary pediatric intensive care units (PICUs) during a single bronchiolitis season. Infants aged 1-24 months requiring HFNC for severe bronchiolitis were randomized to standard care or a nurse-driven protocol group. The intervention included structured assessments using the Wang Bronchiolitis Severity Score (WBSS), and ROX index (SpO
conclusionA nurse-driven HFNC protocol is associated with reduced therapy duration and hospitalization in infants with bronchiolitis without increasing adverse outcomes. Empowering nurses with standardized tools may support timely and effective respiratory care in the PICU.
trial registrationClinicalTrials.gov (NCT06621641), registered on November 22, 2025. WHAT IS KNOWN: • High-flow nasal cannula (HFNC) therapy is widely used in infants with bronchiolitis, despite inconsistent evidence regarding its impact on length of stay and the need for escalation of care. • Lack of standardized weaning criteria may contribute to prolonged HFNC use and increased resource utilization. WHAT IS NEW: • This randomized controlled study demonstrates that a nurse-driven HFNC weaning protocol significantly reduces HFNC duration and hospital length of stay in infants with severe bronchiolitis. • Structured, score-guided nurse-driven weaning can be safely implemented in the PICU without increasing the need for non-invasive ventilation or intubation.
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Registered trials
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