ArticleScientific reports2026
GC-MS profiling, biological activities and molecular docking of total sterol extracts from Pontederia crassipes (Lake Tana, Ethiopia).
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This research aimed to investigate, for the first time, the antioxidant, anti-aging, antidiabetic, and antibacterial activities of the total sterol extract from the aerial parts of Pontederia crassipes collected from Lake Tana, Ethiopia. The plant material was extracted using a specific extraction process to get the total sterol extract. Antioxidant activities were investigated using 1, 1-Diphenyl-2-picrylhydrazyl, 2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid and iron chelation assays. Anti-aging and antidiabetic activities were explored using in vitro enzymatic spectrophotometric methods. The antimicrobial activity was assessed against Pseudomonas aeruginosa and its ability to impede bacterial biofilm production as well as swimming and swarming mobilities. As results stigmasterol and β-sitosterol wereidentified as major constituents of the total sterol extract by GC-MS analysis. The findings showed that the total sterol extract possessed antioxidant activities in all the bioassays and a promising antiaging effect with significant anti-tyrosinase, anti-collagenase, and anti-elastaseactivities. Moderate inhibitory effects on α-amylase and α-glucosidase activities were observed in the plant extract. Moreover, the total sterol extract induced a significant antibiofilm activity in P. aeruginosa at sub-inhibitory concentrations. Furthermore, the extract showed no sign of toxicity against human epidermal keratinocytes and human skin fibroblast cell lines. Molecular docking analyses confirmed that the major compounds identified by GC-MS exhibited more negative binding energies toward the target proteins, indicating stronger binding affinities. These in silico findings support the moderate antidiabetic and anti-aging activities observed experimentally, providing mechanistic insight into the inhibition of the corresponding enzymes. Overall, the results suggest that the aerial parts of P. crassipes are a sterol-rich source with potential applicability in skin-care formulations and possible health-promoting effects, including supportive roles in diabetes management, warranting further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.