Evidence map›Paper›PMID 41865967›Full record

ArticleEnvironmental research2026

Serum PFAS concentrations and neuromorphometry in adolescents: The HOME Study.

Jasmine Haraburda, Jonathan Dudley, Kimberly Yolton, Yingying Xu, Joseph M Braun, Aimin Chen, Bruce P Lanphear, Kim M Cecil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasmine HaraburdaUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jonathan DudleyImaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Bruce P LanphearDepartment of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Kim M CecilImaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: kim.cecil@cchmc.org.

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIAU01AG088658 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Aimin Chen, Lifang Hou · 2024 to 2026
$6.5M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)R01ES031621 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, RYAN, PATRICK H · 2021 to 2025
$5.3M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimagingR01ES033054 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2021 to 2025
$3.3M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
NIA NIH HHS U01 AG088658NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES028277NIEHS NIH HHS R01 ES031621NIEHS NIH HHS R01 ES033054
6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) are a ubiquitous class of persistent synthetic chemicals used in consumer and commercial products for decades. PFAS crosses the blood-placenta and blood-brain barriers to accumulate in the fetus, but the impact on neuroanatomy in early adolescence is unknown.

objectivesWe estimated the association of gestational and early adolescent PFAS concentrations with brain morphometry in 155 participants of the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort enrolled from 2003 to 2006.

methodsWe measured serum PFAS concentrations during gestation and at age 12. We acquired high resolution anatomical brain MRI to quantify global and regional volumes, cortical thickness and sulcal depth using morphometric methods at age 12. We used a general linear model framework with adjustment for adolescent biological sex, race, household income, maternal IQ, maternal pre-pregnancy BMI, primipara, and total intracranial volume.

resultsA doubling in age 12 perfluorooctanoic acid (PFOA) [f

conclusionHigher PFAS concentrations are concurrently associated with larger structural volumes and cortical thickness. The significance is uncertain but are consistent with delayed maturation processes delaying synaptic pruning.

Indexed as

Alkanesulfonic AcidsBrainCaprylatesEnvironmental PollutantsFluorocarbonsAdolescentChildFemaleHumansMagnetic Resonance ImagingMalePregnancyProspective StudiesAlkanesulfonic AcidsCaprylatesEnvironmental PollutantsFluorocarbonsperfluorooctane sulfonic acidperfluorooctanoic acidAdolescentMagnetic resonance imagingNeuromorphometryPer- and polyfluoroalkyl substances

Identifiers

PMID41865967
PMCPMC13162322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.