Evidence map›Paper›PMID 41865356›Full record

SynthesisCardiovascular and interventional radiology2026

Mechanical Thrombectomy Versus Anticoagulation in Intermediate-Risk Pulmonary Embolism: A Systematic Review and Meta-Analysis.

James M Chan, Valeria V Varela Betancourt, Julia Mosqueira Almeida, Anggie L Renteria Chamorro, Li H Tan, Elisa Licari, Hui Yin Lim, Goran Mitreski, Hong Kuan Kok

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James M ChanFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia. jamesc3@unimelb.edu.au.ORCID http://orcid.org/0000-0002-1971-8800
Valeria V Varela BetancourtSchool of Medicine, National University of Colombia, Bogotá, Colombia.
Julia Mosqueira AlmeidaFaculdade de Medicina de Barbacena, FAME/FUNJOB, Barbacena, Brazil.
Anggie L Renteria ChamorroUniversidad Santiago de Cali, Palmira, Colombia.
Li H TanDepartment of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, VIC, Australia.
Elisa LicariDepartment of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, VIC, Australia.
Hui Yin LimFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
Goran MitreskiFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
Hong Kuan KokFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe performed a systematic review and meta-analysis comparing mechanical thrombectomy to anticoagulation in patients with intermediate-risk pulmonary embolism (PE) focusing on patient-centred outcomes. MATERIALS AND

methodsPubMed, Embase and Cochrane databases were searched from inception to November 2025 for randomised controlled trials and observational studies comparing mechanical thrombectomy (with or without anticoagulation) to anticoagulation alone in patients with intermediate-risk PE. The main outcomes were all-cause in-hospital mortality, all-cause 30-day mortality, hospital length of stay and ICU length of stay.

resultsWe identified seven studies, comprising 2699 patients from one randomised controlled trial and six observational studies. Mechanical thrombectomy, compared to anticoagulation, was associated with significantly lower incidence of all-cause 30-day mortality (OR 0.09; 95% CI 0.02-0.41; p = 0.002; I

conclusionIn patients with intermediate-risk PE, mechanical thrombectomy was associated with a lower incidence of all-cause 30-day mortality compared to anticoagulation. However, as the majority of the included studies were observational, these findings should be interpreted with caution and warrant confirmation with further high-quality randomised controlled trials.

Indexed as

AnticoagulantsPulmonary EmbolismThrombectomyHospital MortalityHumansLength of StayTreatment OutcomeAnticoagulantsAnticoagulationClinical outcomesMechanical thrombectomyPulmonary embolism

Identifiers

PMID41865356
PMCPMC13212738

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.