Evidence map›Paper›PMID 41865216›Full record

ReviewJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2026

Technical challenges and prospects for ex vivo heart perfusion: a republication of the review published in Japanese journal of artificial organs.

Daisuke Sakota, Ryo Kosaka, Eiki Nagaoka, Tomoki Tahara, Katsuhiro Ohuchi, Tetsuhito Kigata, Ichiro Sakanoue, Tomoyuki Fujita, Toshihiro Okamoto

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daisuke SakotaHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan. sakota.ao@aist.go.jp.ORCID http://orcid.org/0000-0002-7480-6213
Ryo KosakaHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Eiki NagaokaDepartment of Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Tomoki TaharaDepartment of Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Katsuhiro OhuchiDepartment of Clinical Engineering, Faculty of Medical Science, Juntendo University, Urayasu, Japan.
Tetsuhito KigataDivision of Animal Life Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan.
Ichiro SakanoueDepartment of Thoracic Surgery, Kyoto University, Kyoto, Japan.
Tomoyuki FujitaDepartment of Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Toshihiro OkamotoDepartment of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ex vivo heart perfusion (EVHP) has been clinically utilized for the preservation and functional assessment of donor hearts before heart transplantation. In the field of EVHP research, perfusion methods are often referred to as “modes”. This manuscript describes the characteristics of the EVHP modes that have been proposed to date. The resting mode (Langendorff mode) involves cannulation of the aorta and exclusive coronary perfusion. It is the simplest EVHP mode, and all currently available clinical EVHP systems employ this perfusion method. In contrast, the working mode allows perfusate inflow from the left atrium, thereby generating preload and enabling cardiac output. In our experimental studies, the working mode demonstrated enhanced myocardial metabolism compared with the resting mode; however, it was also associated with increased energy consumption due to cardiac contraction. To address this issue, we developed a left ventricular assist device (LVAD) mode, in which cardiac contraction is supported by a LVAD pump operating in the working mode. LVAD mode was associated with significantly better cardiac function than the resting and working mode. The preservation of cardiac function during EVHP is considered to be greatly influenced by the perfusion mode. Further development of optimized modes will be essential for the effective preservation and evaluation of donor hearts in the future. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2024 (Vol. 53, No. 3, pp. 210–215).

Indexed as

Heart TransplantationOrgan PreservationPerfusionAnimalsHeartHeart-Assist DevicesHumansJapanEx vivo heart perfusionHeart transplantationLeft ventricular assist deviceResting modeWorking mode

Identifiers

PMID41865216
PMCPMC13005804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.