Evidence map›Paper›PMID 41865212›Full record

ArticleObesity surgery2026

Association of Total Small Bowel Length with Glycaemic Control and Metabolic Syndrome in Metabolic and Bariatric Surgery Patients: A Cross-Sectional Study in a Taiwanese Cohort.

Choon Woon Ngo, Nilay Rai, Mohd Kamarulariffin Kamarudin, Ming-Che Hsin, Chih-Kun Huang

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Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Choon Woon NgoDepartment of General Surgery, Enche' Besar Hajjah Khalsom Kluang Hospital, Johor, Malaysia. choonwoon84@yahoo.com.
Nilay RaiJames Paget University Hospital, Great Yarmouth, UK.
Mohd Kamarulariffin KamarudinNational Institute of Health, Ministry of Health Malaysia, Shah Alam, Malaysia.
Ming-Che HsinBody Science and Metabolic Disorders International Medical Center, China Medical University, Taichung, Taiwan.
Chih-Kun HuangBody Science and Metabolic Disorders International Medical Center, China Medical University, Taichung, Taiwan. dr.ckhuang@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe small intestine plays a vital role in nutrient absorption, hormone regulation, and glucose metabolism. Anatomical variability in total small bowel length (TSBL) may contribute to differences in metabolic outcomes. Although TSBL varies significantly between individuals, its relationship with glycaemic control and metabolic syndrome remains under-investigated. This study aimed to assess the relationship between TSBL, glycated haemoglobin (HbA1c), and metabolic syndrome in patients undergoing primary bariatric bypass surgery.

methodsThis cross-sectional study included 478 patients who underwent standardized intraoperative TSBL measurement at a high-volume bariatric center in Taiwan. Individuals on antidiabetic medications or with significant renal dysfunction were excluded. Associations between TSBL and clinical parameters were analyzed using univariate and multivariate regression models, adjusting for sex, height, body mass index (BMI), and other relevant covariates.

resultsLonger TSBL was independently associated with higher HbA1c levels and a greater likelihood of metabolic syndrome, even after adjustment for BMI and other confounders. The final multivariate model explained 13.1% of the variance in TSBL (R² = 0.131).

conclusionThese findings suggest that intestinal morphology may influence metabolic regulation beyond the effects of obesity alone. Anatomical variation in small bowel length could represent a previously underappreciated determinant of glycaemic control and metabolic risk. Further multi-center prospective studies are warranted to elucidate the physiological mechanisms linking bowel length to metabolic function and to inform personalized surgical strategies.

Indexed as

Bariatric SurgeryGlycemic ControlIntestine, SmallMetabolic SyndromeObesity, MorbidAdultBlood GlucoseBody Mass IndexCross-Sectional StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedTaiwanBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanGlycaemic controlHbA1cMetabolic syndromeTotal small bowel length

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.