Evidence map›Paper›PMID 41865100›Full record

ArticleScientific reports2026

White matter microstructure and its association with visuospatial processing development during early infancy.

Narmin Javadova, Marissa Ann DiPiero, Christy D Yoon, Corrina Frye, Andrew L Alexander, H Hill Goldsmith, Richard J Davidson, Elizabeth M Planalp, Douglas C Dean

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Narmin JavadovaDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Marissa Ann DiPieroWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Christy D YoonWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Corrina FryeWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Andrew L AlexanderWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
H Hill GoldsmithWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Richard J DavidsonWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Elizabeth M PlanalpWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Douglas C DeanDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. deaniii@wisc.edu.

Funding

Summer Research ExperienceP50MH100031 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2013 to 2017
$10.4M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Validating RDoC for Children and Adolescents: A Twin Study with NeuroimagingR01MH101504 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDSMITH, HAROLD HILL · 2014 to 2017
$2.4M
Neurobehavioral Development of Emotion Regulation in Young ChildrenK01MH113710 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI PLANALP, ELIZABETH · 2018 to 2021
$531k
Eunice Kennedy Shriver National Institute of Child Health and Human Development T32HD007489NICHD NIH HHS P50 HD105353NICHD NIH HHS T32 HD007489NIMH NIH HHS K01 MH113710NIMH NIH HHS P50 MH100031NIMH NIH HHS R00 MH11059NIMH NIH HHS R01 MH101504
6 · The paper itself

Abstract

This study assessed relations between white matter microstructure at one month of age and visuospatial processing abilities at six months of age. Participants included ninety-one infants (n = 48 female) born after singleton non-complicated pregnancy. The infants underwent MRI at one month of age and a behavioral assessment at six months of age. Results revealed that the intensity of toy play was associated with fractional anisotropy (FA) of the right (t = 3.002, adjusted p = 0.038) and left superior cerebellar peduncle (t = 2.799, adjusted p = 0.038) and right cingulate gyrus (t = 2.908, adjusted p = 0.0038) while Gaze Shifting was associated with mean diffusivity and axial diffusivity of the right superior cerebellar peduncle (t = 3.099, adjusted p = 0.048). No other correlations, including those studied interactions with biological sex, were significant after adjusting for multiple comparisons. The findings support the notion that developing white matter microstructure, as measured by diffusion MRI metrics, plays a role in the development of visuospatial processing. Future studies should explore how these relationships develop and predict visuospatial ability and working memory later in life.

Indexed as

Spatial ProcessingVisual PerceptionWhite MatterAnisotropyDiffusion Tensor ImagingFemaleHumansInfantMaleBiological sexCerebellumDiffusion MRIDTINODDIVisuospatial processing

Identifiers

PMID41865100
PMCPMC13149741

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.