Evidence map›Paper›PMID 41865092›Full record

ArticleScientific reports2026

The most important features in generalized additive models might be groups of features.

Tomas Bosschieter, Luis França, Jessica Wolk, Yiyuan Wu, Bella Mehta, Joseph Dehoney, Orsolya Kiss, Fiona C Baker, Qingyu Zhao, Rich Caruana and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomas BosschieterInstitute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA. tomasbos@alumni.stanford.edu.
Luis FrançaMicrosoft Research, Redmond, WA, 98052, USA.
Jessica WolkMicrosoft Research, Redmond, WA, 98052, USA.
Yiyuan WuHospital for Special Surgery, New York City, NY, 10021, USA.
Bella MehtaHospital for Special Surgery, New York City, NY, 10021, USA.
Joseph DehoneyDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Orsolya KissSRI International, Menlo Park, CA, 94025, USA.
Fiona C BakerSRI International, Menlo Park, CA, 94025, USA.
Qingyu ZhaoWeill Cornell Medicine, Cornell University, New York City, NY, 10065, USA.
Rich CaruanaIntelligible, Inc., Seattle, WA, 98700, USA.
Kilian M PohlDepartment of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.

Funding

Deconstructing Disparities in Lupus PregnanciesK23AR082991 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI Bella Mehta · 2024 to 2026
$528k
NIAMS NIH HHS K23 AR082991NIH HHS R01-AA005965
6 · The paper itself

Abstract

While analyzing the importance of features has become ubiquitous in interpretable machine learning, the joint signal from a group of related features is sometimes overlooked or inadvertently excluded. Neglecting the joint signal could bypass a critical insight: in many instances, the most significant predictors are not isolated features, but rather the combined effect of groups of features. This can be especially problematic for datasets that contain natural groupings of features, including multimodal datasets. This paper introduces a novel approach to determine the importance of a group of features for Generalized Additive Models (GAMs) that is efficient, requires no model retraining, allows defining groups posthoc, permits overlapping groups, and remains meaningful in high-dimensional settings. We showcase properties of our method on three synthetic experiments that illustrate the behavior of group importance across various data regimes. We then demonstrate the importance of groups of features in identifying depressive symptoms from a multimodal neuroscience dataset, and study the importance of social determinants of health after total hip arthroplasty. These two case studies reveal that analyzing group importance offers a more accurate, holistic view of medical issues compared to a single-feature analysis.

Indexed as

Machine LearningAlgorithmsArthroplasty, Replacement, HipDepressionHumansFeature importanceHealthcareInterpretabilityMachine learningNeuroscience

Identifiers

PMID41865092
PMCPMC13144328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.