ArticleScientific reports2026
Capsular polysaccharides of Acinetobacter baumannii modulate antimicrobial resistance and innate immune response.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Synthesis and In Vitro Biological Evaluation of Amphiphilic Derivatives of Carvacrol as Potent Antibacterial Agents.Antibiotics (Basel, Switzerland) · 2026Article
- Using the Damage Response Framework as a Lens to Discuss Acinetobacter baumannii Host-Pathogen Interactions: A Narrative Review and a Call to Action.Infectious diseases and therapy · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
Acinetobacter baumannii is an opportunistic pathogen characterised by multidrug resistance and is among the leading causes of nosocomial infections. This study investigated the role of capsular polysaccharides (CPS) in antimicrobial resistance and host-pathogen interaction. CPS-deficient mutant (∆galU) displayed increased susceptibility to gentamicin, tetracycline, colistin, and sodium dodecyl sulfate (SDS). In the absence of CPS, bacteria adapted by forming biofilm, characterised by a thicker extracellular matrix. These biofilms displayed increased resistance to colistin, chlorhexidine, and hydrogen peroxide, but remained sensitive to tetracycline and SDS. CPS were also essential for the resistance to photodynamic therapy induced by blue light and chlorophyllin. Gene expression analysis revealed upregulation of galU gene under the exposure to antibiotics, blue light, fetal bovine serum, and during the contact with macrophages. CPS-deficient mutant and its derived outer membrane vesicles elicited a stronger pro-inflammatory response, compared to wild-type. CPS shielding A. baumannii demonstrated the ability to induce caspase-3 activation to a greater extent compared to the mutant strain. Moreover, purified CPS induced pro-inflammatory cytokine expression in sterile infection and promoted neutrophil chemotaxis. Altogether, this study demonstrates that CPS not only mask A. baumannii virulence surface structures, but also actively modulate host immune response and antimicrobial resistance.
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