Evidence map›Paper›PMID 41865031›Full record

ArticleNature communications2026

X-ray preactivated reversible persistent luminescence enables photodynamic immunotherapy of deep tumors.

Win Topatana, Yuchao Sun, Tianao Xie, Yiyuan Zhu, Taorui Yang, Ruijing Shen, Peng Ran, Chengao Li, Jiadong Chen, Xuqiu Shen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Win Topatana *Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-8580-1920
Yuchao Sun *Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Tianao Xie *Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Yiyuan Zhu *State Key Laboratory of Silicon and Advanced Semiconductor Materials, Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, China.
Taorui YangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Ruijing ShenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Peng RanState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
Chengao LiState Key Laboratory of Silicon and Advanced Semiconductor Materials, Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, China.
Jiadong ChenDepartment of Chemistry, Zhejiang University, Hangzhou, China.
Xuqiu ShenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Ziyi LuDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Yina HanDepartment of Pathology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Yukai ShanDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Shijie LiDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Tianen ChenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Xiujun CaiDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China. srrsh_cxj@zju.edu.cn.ORCID http://orcid.org/0000-0002-6457-0577
Renren DengState Key Laboratory of Silicon and Advanced Semiconductor Materials, Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, China. rdeng@zju.edu.cn.ORCID http://orcid.org/0000-0001-8213-6304
Sarun JuengpanichDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China. 21718716@zju.edu.cn.ORCID http://orcid.org/0000-0002-1449-5564
Mingyu ChenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China. mychen@zju.edu.cn.ORCID http://orcid.org/0000-0001-5113-754X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52173290National Natural Science Foundation of China (National Science Foundation of China) 82202873National Natural Science Foundation of China (National Science Foundation of China) 82473007National Natural Science Foundation of China (National Science Foundation of China) T2122003National Natural Science Foundation of China (National Science Foundation of China) W2433188Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LR25H160001
6 · The paper itself

Abstract

Persistent luminescence is a promising approach for photodynamic therapy (PDT) in deep-seated tumors, as it provides sustained light within tissues, eliminating the need for continuous external illumination. However, the uncontrollability of light within the body complicates precise spatiotemporal regulation. In this study, we report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles (ETPNs), featuring reversible "on-off" afterglow properties. The excellent afterglow properties of X-ray-activated porous NaYF

Indexed as

ImmunotherapyNanoparticlesNeoplasmsPhotochemotherapyAnimalsCell Line, TumorcGAS-STING Signaling PathwayChlorophyllidesDNA DamageFemaleHumansLuminescenceMicePhotosensitizing AgentsPorphyrinsReactive Oxygen SpeciesChlorophyllidesPhotosensitizing AgentsphytochlorinPorphyrinsReactive Oxygen Species

Identifiers

PMID41865031
PMCPMC13172493

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.