Evidence map›Paper›PMID 41864997›Full record

ArticleCell death & disease2026

Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network.

Rui Qian, Zhipeng Zhao, Xuanxuan Sun, Benkai Xin, Peipei An, Ting Yang, Ning Wu, Xin Hu, Youzhong Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui QianCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Zhipeng ZhaoDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Xuanxuan SunCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Benkai XinCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Peipei AnCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Ting YangCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Ning WuDepartment of Radiation Oncology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Xin HuJilin Provincial Key Laboratory of Cancer Biology, Changchun, China.ORCID http://orcid.org/0000-0002-5105-8929
Youzhong WanCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China. wanyouzhong@jlu.edu.cn.ORCID http://orcid.org/0000-0002-9818-9555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear actin filament is required for efficient repair of DNA double-strand breaks. While cancer-associated SF3B1 mutation leads to impaired DNA repair, the underlying mechanism remains elusive. Here, we found that SF3B1 mutation led to defective nuclear actin network during DNA repair. Mechanistically, SF3B1 mutation increased the expression of circATP9B, which interacted with and facilitated the degradation of MYH9. MYH9 deficiency abolished the assembly of nuclear actin network, which, in turn, suppressed the movement and clustering of DNA damage foci, resulting in inefficient DNA repair. Together, our study reveals a novel mechanism by which SF3B1 mutation influences cancer progression via circRNA, and underscores the important role of MYH9 in organization of nuclear actin network.

Indexed as

ActinsCell NucleusDNA RepairMutationNeoplasmsPhosphoproteinsRNA Splicing FactorsAnimalsCell Line, TumorHumansMyosin Heavy ChainsActinsMyosin Heavy ChainsPhosphoproteinsRNA Splicing FactorsSF3B1 protein, human

Identifiers

PMID41864997
PMCPMC13039298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.