Evidence map›Paper›PMID 41864905›Full record

ArticleCardiovascular diabetology2026

Circulating cardiometabolic metabolite profiles associated with ambient air pollution and atrial fibrillation risk: a prospective cohort study.

Tonghuan Shi, Chaojun Yang, Zhixing Fan, Marcel Sieme, Melina Tangos, Xingyue Wu, Miao Lin, Dizhe Huang, Benjamin Sasko, Jan Wintrich and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tonghuan Shi *Ruhr-University Bochum, Medical Faculty, Institute of Physiology, Department of Cellular and Translational Physiology, Bochum, Germany.
Chaojun Yang *Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443003, Yichang, China.
Zhixing Fan *Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443003, Yichang, China. fanzhixing@ctgu.edu.cn.
Marcel SiemeRuhr-University Bochum, Medical Faculty, Institute of Physiology, Department of Cellular and Translational Physiology, Bochum, Germany.
Melina TangosRuhr-University Bochum, Medical Faculty, Institute of Physiology, Department of Cellular and Translational Physiology, Bochum, Germany.
Xingyue WuKey Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China.
Miao LinKey Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China.
Dizhe HuangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Benjamin SaskoMedical Department II, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
Jan WintrichMedical Department II, Marien Hospital Herne, Ruhr University Bochum, Bochum, Germany.
Muchtiar KhanDepartment of Cardiology, OLVG, Amsterdam, The Netherlands.
Xinyi LiuDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443003, Yichang, China.
Assem AweimerDepartment of Cardiology and Angiology, University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany.
Andreas MüggeDepartment of Cardiology and Angiology, University Hospital St. Josef- Hospital, Ruhr University Bochum, Bochum, Germany.
Ibrahim AkinFirst Department of Medicine, University Medical Centre Mannheim (UMM), Mannheim, Germany.
Loek van HeerebeekDepartment of Cardiology, OLVG, Amsterdam, The Netherlands.
Ibrahim El-BattrawyRuhr-University Bochum, Medical Faculty, Institute of Physiology, Department of Cellular and Translational Physiology, Bochum, Germany.
Giuseppe Danilo NorataDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, Milan, Italy.
Ulrich SchottenDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Francesco PaneniCenter for Translational and Experimental Cardiology (CTEC), Zurich University Hospital, University of Zurich, Zurich, Switzerland.
Kai HuangHubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, China. huangkai1@hust.edu.cn.
Jian YangDepartment of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, 443003, Yichang, China. yangjian@ctgu.edu.cn.
Nazha HamdaniRuhr-University Bochum, Medical Faculty, Institute of Physiology, Department of Cellular and Translational Physiology, Bochum, Germany. nazha.hamdani@ruhr-uni-bochum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmbient air pollution has been linked to atrial fibrillation (AF), yet the underlying metabolic mechanisms remain poorly understood.

methodsWe analyzed 227,324 UK Biobank participants without baseline AF. We constructed an air pollution score by aggregating all four pollutants (PM

resultsDuring follow-up, 16,235 participants (7.14%) developed AF. We identified 65-metabolite signature significantly associated with air pollution, predominantly comprising lipoprotein lipid concentrations (32.31%), lipoprotein subclasses (15.38%), fatty acids (13.85%), and amino acids (12.31%). Each standard deviation increase in this metabolic signature was associated with 18% higher AF risk (HR = 1.18, 95%CI:1.03-1.35). The metabolic profile mediated 15.45% of the relationship between air pollution and AF, with lipoprotein parameters showing the strongest mediation effects.

conclusionAir pollution-related metabolic signature was independently associated with AF risk and mediated a significant portion of pollution's arrhythmogenic effects. These findings provide novel insights into biological mechanisms linking environmental exposures to AF.

Indexed as

Air PollutantsAir PollutionAtrial FibrillationMetabolomicsParticulate MatterAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsTime FactorsUK BiobankAir PollutantsBiomarkersParticulate MatterAir pollutionAtrial fibrillationLipoproteinMetabolomic

Identifiers

PMID41864905
PMCPMC13130729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.