Trial reportBMC neurology2026
Changes in cognitive performance following combined CogSMART-SA and BrainHQ interventions: a pilot study.
Trial report in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06466642 (Building Resources to Achieve Improvement in Neurocognition), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Building Resources to Achieve Improvement in Neurocognition (B.R.A.I.N) in People Living With HIV
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Authors and funding
8 authors.
Funding
Abstract
backgroundDespite effective antiretroviral treatment, neurocognitive impairment (NCI) and functional disability remain concerningly prevalent among people living with HIV (PLWH). Despite this, there are currently no adequate evidence-based treatments targeting NCI in PLWH who reside in low- and middle -income countries. This is a major public health concern given that most the global population of PLWH is concentrated in those countries. Studies emerging from high-income countries of the global north suggest that different forms of cognitive remediation therapy (e.g., compensatory cognitive training [CCT] and restorative computer-based cognitive remediation training [CCRT]) may be helpful in treating NCI in PLWH. This developmental pilot study is the first to culturally adapt and pilot test a CCT approach (CogSMART) and a CCRT approach (BrainHQ©) for use in African PLWH.
methodForty-three participants (mean age = 41.1 ± 5.4 years) were randomized into either an intervention group (n = 27) or a matched-contact control group (n = 16). All participants completed a neuropsychological test battery and self-report measures of mental health and everyday functional competencies at baseline and at study exit. Participants assigned to the intervention group completed 10 CogSMART and 20 BrainHQ© sessions over the 5 weeks between baseline and exit testing.
resultsA significantly smaller proportion of intervention-group participants met criteria for neurocognitive impairment at study exit (30%) than at baseline (70%). Mixed-model analyses detected a significant and a noteworthy time x group interaction effect for the two cognitive outcomes, Global Deficit Score (p < 0.001) and delayed verbal memory (p = 0.050). In both cases, intervention-group participants made greater cognitive gains than controls participants over the 5-week trial period.
conclusionsCulturally adapted cognitive remediation therapy shows good potential to reduce symptoms of NCI among South African PLWH. Reduction of such symptoms could, in turn, lead to better quality of life and other functional and health improvements. However, the current results must be replicated using larger-scale randomized controlled trials in the same setting. Future research should also seek to better understand the barriers to, and facilitators of successful implementation of neurorehabilitation interventions for NCI among PLWH in low- and middle-income countries.
trial registrationClinicalTrials.gov NCT06466642.
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