ArticleBMC genomics2026
The tiger who came to T2T: Telomere-to-Telomere genome assembly of the Sumatran tiger (Panthera tigris sumatrae) using nanopore simplex reads.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundChromosome-level de novo genome assemblies are vital for many aspects of biological research. Despite technological progress, achieving telomere-to-telomere assemblies remains challenging. Long-read data are critical for a contiguous genome assembly, since repeat regions cannot be assembled without them. Researchers typically generate substantial quantities of data from multiple sequencing platforms to achieve accurate and contiguous telomere-to-telomere (T2T) assemblies. This makes the process costly and complicated. Recent advances in algorithms designed to optimise assembly with long-read data have the potential to rectify this issue. Using only Oxford Nanopore Technology (ONT) simplex long-read data from the Sumatran tiger (Panthera tigris sumatrae), we evaluate leading methods for error correction of long-reads (NextDenovo, HERRO and hifiasm ONT) and various assembly approaches.
resultsWe show that correcting errors in ONT long-reads during assembly greatly improves the quality and contiguity of the resulting assembly, suggesting these methods will make high quality genome assemblies more achievable with less data. We also present the first, almost complete, T2T, de novo genome assembly for the Sumatran tiger, with a single technology.
conclusionsThis assembly is a novel resource for genomic research and conservation efforts.
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