SynthesisBMC infectious diseases2026
Prevalence and determinants of urinary tract infection among Ethiopian children: a systematic review and meta-analysis of institution-based studies.
Synthesis in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPediatric urinary tract infections (UTIs) are a major source of morbidity, often leading to severe complications like renal scarring, hypertension, and chronic kidney disease if not treated promptly. In Ethiopia, current data remains sparse and fragmented across single-institution studies. This synthesis pools existing evidence to provide a comprehensive national estimate of bacterial UTI prevalence and its primary determinants.
methodsThis systematic review and meta-analysis followed PRISMA guidelines and involved a comprehensive search of PubMed, Medline, HINARI, ScienceDirect, Scopus and Google Scholar for literature published through August 15, 2025. The inclusion criteria focused on non-randomized studies reporting the prevalence of UTIs and/or associated factors among children (age < 18 years) in Ethiopia. Data were extracted using a standardized template encompassing the author, publication year, study area/setting, prevalence, study population, participant count and reported factors. Risk of bias was appraised using the Newcastle-Ottawa Scale. Statistical analysis was conducted in STATA version 17. A random-effects meta-analysis was employed to calculate pooled prevalence and Odds Ratios with 95% Confidence Intervals. Heterogeneity was quantified using the I
resultsA total of 13 studies involving 3,951 children met the inclusion criteria. The pooled prevalence of bacterial UTI was found to be 23.17% (95% CI: 18.40%-27.93%). The meta-analysis of associated factors was identified history of previous UTI (OR = 2.47, 95% CI: 1.66 - 3.68), history of catheterization (OR = 2.95, 95% CI: 1.78 - 4.91) and hospital stay longer than four days (OR = 2.65, 95% CI: 1.75 - 4.00) as significant predictors of UTI.
conclusionUrinary tract infections (UTIs) represent a significant clinical burden driven primarily by a history of previous infections, prior catheterization and prolonged hospital stays exceeding four days. To mitigate this risk, implementation of targeted screening protocols and evidence-based preventive measures: minimizing unnecessary catheterization and reducing hospital length of stay whenever medically feasible, is recommended to proactively lower infection rates. CLINICAL TRIAL: Not applicable.
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