ArticleInternational dental journal2026
Proteomic Profiling of PTEN Inhibition on Periodontal Ligament Stem Cells.
Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Biological mechanisms governing the periodontal regenerative microenvironment: cellular crosstalk, extracellular matrix remodelling, and immunomodulation.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePhosphatase and tensin homolog (PTEN) is a critical regulator of cell proliferation, differentiation, and inflammatory balance. However, its downstream proteomic effects in periodontal ligament stem cells (PDLSCs) remain poorly understood. This study aimed to elucidate the proteomic alterations induced by PTEN inhibition and identify potential molecular pathways underlying periodontal regeneration. MATERIALS AND
methodsPDLSCs were treated with 5 μM VO-OHpic for 24 hours, followed by proteomic profiling using mass spectrometric analysis. The resulting proteomic data were analysed using Heatmapper, Metascape, and WebGestalt (WEB-based Gene Set Analysis Toolkit) databases, as well as Cytoscape, to evaluate protein expression patterns and protein-protein interaction networks.
resultsProteomic analysis identified 7,525 proteins across all samples, with 3,497 proteins commonly expressed between groups. In the VO-OHpic-treated cells, proteins related to cytoskeletal dynamics (ACTR2, FNDC3A), vesicular transport (GGA1, RAB9A), and signal transduction (TRAF3IP3, GJB3) were upregulated. Enrichment analysis identified potential biological pathways related to membrane trafficking, secretion, and regulation of MAPK and Wnt signalling. Conversely, proteins linked to transcriptional and metabolic regulation (GLIS3, PHGDH, NADSYN1) and membrane trafficking (SNX1, REEP1) were downregulated. Cytokine signalling and interferon pathways were explored as the potential pathways involved in these downregulated proteins.
conclusionIn conclusion, PTEN inhibition by VO-OHpic was associated with proteomic changes in PDLSCs linked to regenerative phenotype, including the modulation of MAPK and Wnt signalling pathways alongside alterations in immune and metabolic pathways. These findings suggest that PTEN may function as a modulator balancing inflammatory regulation and differentiation processes, providing mechanistic insight into its potential role in periodontal tissue regeneration.
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