Evidence map›Paper›PMID 41863798›Full record

ArticleCell reports2026

Identification and characterization of BRAF⇔TP53 interactions in melanoma.

Kayla T O'Toole, Adamaris Martinez, Brandon Murphy, Gabriela Fort, Fatima Al-Sudani, Anastasia Prokofyeva, Sanjana Boggaram, Eric A Smith, Elliott L Paine, Deevya Baral and 8 more

Abstract read
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kayla T O'TooleHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Adamaris MartinezHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Brandon MurphyHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Gabriela FortHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Fatima Al-SudaniHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Anastasia ProkofyevaHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Sanjana BoggaramHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Eric A SmithHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Elliott L PaineDepartment of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Deevya BaralHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
David LumHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Wei ZhangHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Erika EgalHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Gennie L ParkmanHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Zoology, Weber State University, Ogden, UT, USA.
Eric L SnyderHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Robert Judson-TorresHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Joshua L AndersenHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Martin McMahonHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA; Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA; Department of Dermatology, University of Utah, Salt Lake City, UT, USA. Electronic address: martin.mcmahon@hci.utah.edu.

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Studying the initiation, progression and therapy of lung cancer in mouse modelsR01CA131261 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARTIN MCMAHON · 2009 to 2026
$5.3M
Transcriptional Regulation of Lung Cancer IdentityR01CA212415 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Eric Lee Snyder · 2017 to 2026
$3.2M
Patho-Genetic Analysis of Invasive Mucinous Adenocarcinoma of the LungR01CA240317 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MAEDA, YUTAKA, SNYDER, ERIC LEE · 2020 to 2024
$3.1M
Targeting Oncogenic NRAS, BRAF plus PI3'-Kinase Signaling for Melanoma TherapyR01CA176839 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARTIN MCMAHON · 2013 to 2026
$2.9M
Lineage Specifiers Governing Pancreatic Cancer Growth and Molecular SubtypeR01CA237404 · NCI · UNIVERSITY OF UTAH · PI SNYDER, ERIC LEE · 2020 to 2024
$1.9M
Nevus associated microRNAs as mediators of BRAF-induced growth arrest and biomarkers of melanoma progressionR01CA229896 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JUDSON-TORRES, ROBERT LAIRD · 2021 to 2025
$1.8M
Huntsman Cancer Institute (HCI) Cancer Genetics, Epigenetics, Models, and Signaling (Cancer GEMS) Training ProgramT32CA265782 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Donald E Ayer, Sheri L Holmen · 2023 to 2026
$1.0M
PTM-driven mechanisms of cell signalingR35GM158333 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Joshua Lyon Andersen · 2025 to 2026
$847k
Investigating molecular regulators of a mixed-lineage state in lung adenocarcinomaF31CA275328 · NCI · UNIVERSITY OF UTAH · PI FORT, GABRIELA M · 2022 to 2024
$114k
NCI NIH HHS F31 CA275328NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA131261NCI NIH HHS R01 CA176839NCI NIH HHS R01 CA212415NCI NIH HHS R01 CA229896NCI NIH HHS R01 CA237404NCI NIH HHS R01 CA240317NCI NIH HHS T32 CA265782NIGMS NIH HHS R35 GM158333
6 · The paper itself

Abstract

Activating mutations in BRAF are common in cutaneous melanoma, yet mutational inactivation of the tumor suppressor TP53 is relatively rare despite widespread attenuation of TP53 function, suggesting alternate mechanisms of TP53 inhibition. Using proximity-dependent proteomic mapping, we define a BRAF

Indexed as

BRAFcancerCP: cancermelanomaproteomicsTP53TurboID

Identifiers

PMID41863798
PMCPMC13353105

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.