Evidence map›Paper›PMID 41863792›Full record

ArticleSTAR protocols2026

Protocol for generation of brain metastasis mouse model using stereotactic intracranial tumor-derived cells and modified intracarotid injection.

Thi-Anh-Thuy Tran, Young-Hee Kim, Kyung-Hwa Lee, Sue-Jee Park, Yeong Jin Kim, Kyung-Sub Moon, In-Young Kim, Shin Jung, Tae-Young Jung

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In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thi-Anh-Thuy TranBrain Tumor Research Laboratory, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Young-Hee KimBrain Tumor Research Laboratory, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Kyung-Hwa LeeDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea; BioMedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Hwasun, Republic of Korea.
Sue-Jee ParkDepartment of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Yeong Jin KimDepartment of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Kyung-Sub MoonBrain Tumor Research Laboratory, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea; Department of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
In-Young KimDepartment of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Shin JungBrain Tumor Research Laboratory, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea; Department of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea.
Tae-Young JungBrain Tumor Research Laboratory, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea; Department of Neurosurgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea. Electronic address: jung-ty@jnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we present a protocol for establishing a reproducible mouse model of brain metastasis. We describe the steps for preparing and injecting tumor cells into the internal carotid artery to achieve direct cerebral circulation delivery. We detail procedures for monitoring and validating brain colonization using magnetic resonance imaging (MRI) and histological analysis (H&E staining) and provide guidance on stereotactically generating, harvesting, and re-injecting intracranial tumors via the intracarotid route. This approach enables modeling of brain metastasis and tumor adaptation in the brain microenvironment.

Indexed as

Brain NeoplasmsDisease Models, AnimalStereotaxic TechniquesAnimalsCarotid Artery, InternalCell Line, TumorHumansMagnetic Resonance ImagingMiceCancerHealth SciencesModel OrganismsNeuroscience

Identifiers

PMID41863792
PMCPMC12990365

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.