SynthesisSleep & breathing = Schlaf & Atmung2026
Physiopathological correlations of comorbid insomnia and sleep apnoea (comisa) - a systematic review and meta-analysis.
Synthesis in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comorbid Insomnia and Sleep Apnea Mechanistic Convergence, Phenotypic Heterogeneity, and Clinical Implications.Current sleep medicine reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo ascertain the physiopathological correlations of insomnia and obstructive sleep apnoea (Comorbid Insomnia and Sleep Apnoea (COMISA).
methodsSystematic review and meta-analysis, with searches in PubMed, Embase, Web of Science, Scopus, Cochrane, and grey literature, including physiopathological characteristics and prevalence of COMISA in observational studies. The meta-analysis employed the I² and Cochran’s Q tests, as well as the random effects method, and the results were presented in forest plots. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal tools.
resultsSixteen studies were selected, with a prevalence of 30% for COMISA, 39% among ages 18–40, 42% in European countries, and an average Body Mass Index (BMI) of 28.55 (± 1.12). Patients with COMISA have higher Apnoea-Hypopnea Index (AHI), lower minimum oxygen saturation, higher micro-arousal index, longer wake time after sleep onset Wake Time After Sleep Onset (WASO), lower sleep efficiency, longer sleep latency, and possibly shorter Rapid Eye Movement (REM) sleep duration.
conclusionThe physiopathology of COMISA involves compromised sleep architecture and a complex interaction of mechanisms related to central arousal, sleep fragmentation, neurobiological changes, and a more severe profile of clinical and psychiatric comorbidities, with additive or synergistic consequences of the isolated disorders, requiring a comprehensive and personalized diagnostic and therapeutic approach. PROSPERO Registry number: CRD420251038279.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.