Evidence map›Paper›PMID 41863729›Full record

ArticleEJNMMI radiopharmacy and chemistry2026

An improved fully-automated GMP radiosynthesis of [

Chris Barnes, Frazer Twyman, Ramla O Awais, Dylan Pritchard, Matthias Glaser, David R Turton, Diana Brickute, Graham Smith, Erik Årstad, Louis Allott and 1 more

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In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chris BarnesComprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Frazer TwymanCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, UK.
Ramla O AwaisCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, UK.
Dylan PritchardCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, UK.
Matthias GlaserCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, UK.
David R TurtonDivision of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.
Diana BrickuteComprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Graham SmithDivision of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.
Erik ÅrstadCentre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, UK.
Louis AllottComprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Eric O AboagyeComprehensive Cancer Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK. eric.aboagye@imperial.ac.uk.ORCID http://orcid.org/0000-0003-2276-6771

Funding

Medical Research Council MC-N020782/1
6 · The paper itself

Abstract

backgroundWe previously reported the first-in-human evaluation of 3-[

resultsWe developed a fully-automated SPE purified radiosynthesis on FASTLab™ for GMP readiness that was translated to and validated on the Trasis AIO™ platform for routine clinical use. Purification of the radiotracer by SPE on both systems was achieved (> 98% radiochemical purity), increasing the radiochemical yield compared to the HPLC-based purification method. Non-decay-corrected radiochemical yields (RCY, n.d.c) were 30.3 ± 2.3% (n = 8) and 25.8 ± 6.6% (n = 46) on GE FASTlab™ and Trasis AIO™, respectively. Non-radioactive FPIA and other analytes determined by HPLC were below the limit of detection (< 1.0 µg/mL) from GE FASTlab™ and ≤ 1.2 µg/mL from Trasis AIO™.

conclusionsThe synthesis of [

Indexed as

[18F]fluoropivalic acid[18F]FPIAAutomated radiosynthesisFluorine-18GMP radiopharmaceuticalPET/positron emission tomographySPE purification

Identifiers

PMID41863729
PMCPMC13125436

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