ReviewClinical reviews in allergy & immunology2026
Conductive Mechanisms of Olfactory Dysfunction in Chronic Rhinosinusitis: A Focus on Nasal Airflow Dynamics and Olfactory Mucus.
Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Olfactory dysfunction (OD) secondary to chronic rhinosinusitis (CRS) significantly impairs quality of life by hindering the detection of warning signals and reducing nutritional satisfaction. CRS, a prevalent inflammatory condition, commonly leads to diminished or complete loss of smell. A substantial component of CRS-associated OD is conductive, stemming from impaired odorant delivery to the olfactory neuroepithelium. The tools for assessing conductive OD range from clinical evaluations like endoscopy and CT scoring of the olfactory cleft to objective measures of nasal patency and advanced computational fluid dynamics modeling. The underlying conductive mechanisms are multifactorial, primarily involving two interrelated pathways: alterations in nasal airflow dynamics due to anatomical variations or obstructive lesions, and pathological changes in the physicochemical properties of olfactory cleft mucus. Obstructions from septal deviation, turbinate hypertrophy, nasal polyps, and mucosal edema within the olfactory cleft disrupt and redistribute inspiratory airflow, critically reducing odorant access. Concurrently, inflammation-driven changes in the olfactory mucus—including hypersecretion, ionic imbalance, and deficiencies in odorant-binding proteins and metabolizing enzymes—impair odorant transport, solubilization, and signal transduction. Current therapeutic strategies, such as endoscopic sinus surgery and corticosteroids, aim to relieve these conductive barriers but may offer only partial or temporary benefit, highlighting the need for precise phenotyping. A systematic, individualized assessment of both airflow patterns and mucus properties is crucial for understanding the conductive contribution and predicting outcomes. This review synthesizes current evidence on the conductive mechanisms of olfactory loss in CRS, evaluating the impact of nasal aerodynamics and mucus alterations, and discusses integrated management strategies for this debilitating condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.