Evidence map›Paper›PMID 41863706›Full record

ArticleGeroScience2026

Modeling and evaluating longitudinal brain maintenance and cognitive reserve using episodic memory, brain structure, and functional connectivity in older adults.

Rachel M Morse, Lídia Vaqué-Alcázar, María Cabello-Toscano, Cristina Solé-Padullés, Lídia Mulet-Pons, Juan Pablo Martin Trias, Micael Andersson, Dídac Vidal-Piñeiro, Alvaro Pascual-Leone, Kristine Walhovd and 2 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rachel M MorseDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Lídia Vaqué-AlcázarDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
María Cabello-ToscanoDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Cristina Solé-PadullésDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Lídia Mulet-PonsDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Juan Pablo Martin TriasDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
Micael AnderssonUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Dídac Vidal-PiñeiroCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Alvaro Pascual-LeoneDepartment of Neurology, Harvard Medical School, Boston, MA, USA.
Kristine WalhovdCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway.
Lars NybergUmeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
David Bartres-FazDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain. dbartres@ub.edu.

Funding

California Walnut Commission NCT01634841EU Horizon 2020 732592European Research Council 313440Instituto de Salud Carlos III CD23/00235'la Caixa' Foundation ID: 100010434; fellowship code: B006097National Institute of Health R24-AG061421Spanish Ministry of Economy and Competitiveness (MINECO) PSI2015- 64227-R (AEI/FEDER, UE)Spanish Ministry of Science and Innovation PID2022-137234OB-100
6 · The paper itself

Abstract

Cognitive reserve (CR) and brain maintenance (BM) reflect better than expected cognition despite brain pathology and minimal age-related brain changes that explain stable cognition, respectively. Despite being commonly used, joint quantification of these concepts has been limited; our aim is to derive longitudinal CR and BM measures and investigate CR's relationship with education and functional connectivity. We analyzed longitudinal data from 451 participants (241 female, age

Indexed as

Brain maintenanceCognitionCognitive reserveHealthy agingMemoryResting-state functional connectivity

Identifiers

PMID41863706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.