ArticleJournal of gastrointestinal cancer2026
Vascular Dysfunction in Colorectal Cancer: Scoping Review of Current Evidence for Guiding Future Research.
Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
purposeWe conducted a scoping review of research on vascular function (VF) in colorectal cancer (CRC) survivors and developed a research agenda to address current limitations.
methodsWe applied the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Scoping Review (PRISMA-ScR) when conducting and reporting this review. We searched 3 databases (PubMed, EBSCOhost, and EMBASE) in October 2025 for publications on VF and vascular dysfunction (VD) that included measures of arterial stiffness and endothelial function in CRC survivors. There were 348 manuscripts identified for title and abstract screening, and 341 were excluded for not meeting the inclusion criteria.
resultsOur search and subsequent screening identified seven papers reporting measures of VF in CRC survivors. Five papers focused on the impact of systemic therapies on measures of VF, including PWV and FMD, whereas two papers examined the effect of colon surgery on surrogate measures of VF. Increased arterial stiffness and atherosclerosis were observed following systemic treatment; however, endothelial function was inconsistent. Following colon surgery, endothelial function declined, while arterial stiffness remained unchanged.
conclusionCRC survivors who underwent systemic treatment had increased arterial stiffness and atherosclerosis, and those who underwent colon surgery had endothelial dysfunction. Overall, there is limited research on VF in CRC survivors, and we outline an agenda for future research to investigate VF in this population and address the numerous gaps in the field. IMPLICATIONS FOR CANCER SURVIVORS: This review highlights that CRC survivors may experience vascular health risks following systemic therapy and colon surgery, emphasizing the need for improved VF monitoring and survivorship care.
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