ArticleAnalytical and bioanalytical chemistry2026
ICP-MS/colorimetric dual-mode detection of circulating tumor cells with dual-aptamer recognition based on gold nanoparticles.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Nanomaterial-enabled bioanalytical sensing for doping detection: a critical review of signal transduction, matrix effects, and translation barriers.Analytical and bioanalytical chemistry · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
The efficient identification of circulating tumor cells (CTCs) is vital for early cancer diagnosis and treatment efficacy surveillance. Therefore, developing a CTC detection platform that combines high sensitivity with operational simplicity holds significant value. Dual-mode analytical strategies enhance detection reliability through signal cross-validation, offering a novel approach for constructing such platforms. To this end, this study developed an ICP-MS/colorimetric dual-mode sensing platform incorporating dual-aptamer recognition and gold nanoparticle signal labeling for the precise and sensitive detection of MCF-7 cells, which served as a CTC model. The platform employs magnetic nanoparticles for efficient separation, while gold nanoparticle labeling enables both quantitative ICP-MS analysis and colorimetric readout. Under optimized conditions, the assay achieved a linear range of 200-10,000 MCF-7 cells, with detection limits of 8 cells for ICP-MS and 76 cells for the colorimetric method. In real human blood samples, the spike recovery rate reached 96.90-109.33%, indicating good accuracy and anti-interference capability. The dual-mode strategy proposed in this study integrates high sensitivity with operational convenience. This combination provides a reliable and flexible analytical platform for CTC liquid biopsy and early tumor diagnosis in clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.