Evidence map›Paper›PMID 41863436›Full record

ArticlemAbs2026

Structure-based calculation of excipient effects on the viscosity of concentrated antibody solutions.

John C Shelley, Qing Chai, Lina Wu, Shaghayegh Vafaei, Mee Y Shelley, Eric Feyfant, Jiangyan Feng, Mahlet A Woldeyes, Volodymyr Babin, Jonathan D Jou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

John C ShelleyComputational Chemistry, Schrödinger, Inc., Portland, OR, USA.ORCID 0000-0001-6223-4804
Qing ChaiBioTechnology Discovery Research, Eli Lilly & Co, San Diego, CA, USA.ORCID 0000-0002-6273-905X
Lina WuFormerly at Formulation Development, Eli Lilly & Co, Cambridge, MA, USA.
Shaghayegh VafaeiComputational Chemistry, Schrödinger, Inc., New York, NY, USA.
Mee Y ShelleyComputational Chemistry, Schrödinger, Inc., Portland, OR, USA.
Eric FeyfantComputational Chemistry, Schrödinger, Inc., Cambridge, MA, USA.
Jiangyan FengBioTechnology Discovery Research, Eli Lilly & Co, San Diego, CA, USA.ORCID 0000-0003-0292-6758
Mahlet A WoldeyesBioproduct Research and Development, Eli Lilly & Co, Indianapolis, IN, USA.
Volodymyr BabinComputational Chemistry, Schrödinger, Inc., Portland, OR, USA.
Jonathan D JouComputational Chemistry, Schrödinger, Inc., New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Computational prediction of the viscosity of therapeutic monoclonal antibodies (mAbs) at high concentration is highly desirable in the early discovery and development phases where the material needed for experimental determination is typically limited. Here, we present a unique coarse-grained (CG) simulation method that enables residue-level simulation of full-length antibodies with an elastic network, under simulated shearing force, to

Indexed as

Antibodies, MonoclonalExcipientsImmunoglobulin GHumansMolecular Dynamics SimulationViscosityAntibodies, MonoclonalExcipientsImmunoglobulin Gantibodiesexcipientsformulationmolecular dynamicsnon-equilibriumViscosity

Identifiers

PMID41863436
PMCPMC13007400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.