Evidence map›Paper›PMID 41863255›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.

Claudio Agnorelli, Joseph Peill, Gabriela Sawicka, Danielle Kurtin, Ekaterina Shatalina, Kirran Ahmad, Matthew B Wall, Catarina Rua, Kate Godfrey, Natalie Ertl and 11 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ketamine and Evolving Neuroplasticity.Clinical drug investigation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Claudio AgnorelliCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-9100-7800
Joseph PeillCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.
Gabriela SawickaCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0009-0006-5991-7691
Danielle KurtinCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0001-5368-6737
Ekaterina ShatalinaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0001-8900-0792
Kirran AhmadCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.
Matthew B WallCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-0493-6274
Catarina RuaPerceptive Discovery, Hammersmith Hospital, London, UK.
Kate GodfreyCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.
Natalie ErtlPerceptive Discovery, Hammersmith Hospital, London, UK.
Graham SearlePerceptive Discovery, Hammersmith Hospital, London, UK.
Katie ZhouCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.
Martin OsugoDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-5462-8464
Brandon WeissCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0003-2989-2981
Kyle T GreenwayDepartment of Psychiatry, Faculty of Medicine, McGill University, Montréal, QC, Canada.ORCID 0000-0002-7829-493X
Andrea FagioliniDepartment of Molecular Medicine, Division of Psychiatry, School of Medicine, University of Siena, Siena, Italy.
Robin Carhart-HarrisDepartment of Neurology and Psychiatry, Carhart-Harris Lab, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6062-7150
Paul M MatthewsUK Dementia Research Centre and Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-1619-8328
Eugenii A RabinerPerceptive Discovery, Hammersmith Hospital, London, UK.ORCID 0000-0003-3612-6687
David NuttCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-1286-1401
David ErritzoeCentre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK.ORCID 0000-0002-7022-6211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated ketamine's neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/kg, intravenous). Eleven male participants underwent two PET/MRI scans with [

Indexed as

BrainKetamineNeuronal PlasticityAdultGlutamic AcidGyrus CinguliHealthy VolunteersHumansMagnetic Resonance ImagingMaleMultimodal ImagingPositron-Emission TomographyYoung AdultGlutamic AcidKetamineDefault mode networkketamineMRIneuroplasticityPET

Identifiers

PMID41863255
PMCPMC13005766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.