ArticleCurrent drug safety2026
Magnitude and Predictors of Antimicrobial Use-Related Drug Problems in Geriatric Inpatients: Evaluation of Pharmacist Interventions.
Article in Current drug safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionInfections remain a major cause of illness and death in older adults. Physiological changes, polypharmacy, and chronic conditions complicate antimicrobial therapy and increase the risk of drug problems. Pharmacist-led interventions improve prescribing, but evidence from the United Arab Emirates is limited. This study evaluated the magnitude and determinants of antimicrobial use-related drug problems and assessed clinical pharmacist interventions in hospitalized older adults with infections.
methodsA retrospective observational study was conducted from February to July 2022 at a 350-bed tertiary care academic hospital in the United Arab Emirates. Medical records of patients aged 60 years and older admitted with infections and treated with systemic antimicrobials were reviewed. Drug-related problems were classified using the Hepler and Strand framework.
resultsAmong 102 patients, 85 antimicrobial-related drug problems were identified, with half experiencing at least one. Common categories were drug-drug interactions (29%), unnecessary use (18%), and overdosing (14%). Cephalosporins (21%), penicillins (12%), and fluoroquinolones (12%) were the most frequently implicated classes. Clinical pharmacists made 79 recommendations; 95% were accepted, and 91% were implemented. Main interventions were drug omission (28%), substitution (25%), and dose modification (23%). Prior antimicrobial use, polypharmacy, and longer hospital stay predicted drug problems. DISCUSSION: The high prevalence of antimicrobial use-related drug problems highlights the challenges of polypharmacy and prolonged hospitalization. Findings reinforce the feasibility and acceptance of pharmacist-led interventions, supporting their role in antimicrobial stewardship.
conclusionClinical pharmacists are integral to optimizing antimicrobial therapy and improving medication safety in older adults.
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