ArticleBioMed research international2026
Blood Types May Be Involved in the Occurrence of Coronary Heart Disease Through Serum Lipids.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Blood Types May Be Involved in the Occurrence of Coronary Heart Disease Through Serum Lipids.BioMed research international · 2026Article
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3 authors.
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Abstract
backgroundABO blood types have important clinical significance in medicine. In this paper, our primary objective is to evaluate the association between ABO blood types and coronary heart disease (CHD) in the Chinese population. The secondary objective is to explore whether blood lipids may serve as a potential influencing factor in the relationship between blood types and CHD.
methodsWe collected data from 5188 CHD patients to assess the distribution of blood types between CHD patients and blood donors, and performed binary logistic regression analysis to explore the correlation between blood types and CHD. Subgroup analyses and interactions were conducted to verify the robustness of the findings. Serum biological markers of CHD across different blood types were compared to explore potential underlying mechanisms.
resultsThe proportion of Type A was higher (p = 0.012), and Type O was lower (p = 0.047) in CHD. Logistic regression modeling analyses showed that Type A had a significantly increased risk of CHD by 24% compared with non-A (OR [95% CI] 1.24: 1.05-1.45, p = 0.009). Blood Type A had a consistent effect on the risk of CHD across all subgroups, with no significant interaction observed (p for interaction > 0.1). Further, serum levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) were found to be significantly higher in individuals with Type A CHD compared with those with non-A blood types (p = 0.02, p = 0.045, p = 0.019).
conclusionsType A is an independent risk factor for CHD, and CHD patients with Type A exhibit higher blood lipid levels, suggesting that blood type antigens may be involved in the occurrence of CHD through the lipid pathway.
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