Evidence map›Paper›PMID 41862858›Full record

ArticleBMC pregnancy and childbirth2026

Influence of hormonal status in hereditary hemorrhagic telangiectasia - analysis of an online patient questionnaire.

Freya Droege, Kruthika Thangavelu, Angela Koeninger, Eva Maria Huessler, Stephan Lang, Boris A Stuck, Urban W Geisthoff

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02690246 (A Questionnaire Based Study on Symptoms and Treatment Results in Hereditary Hemorrhagic Telangiectasia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02690246 completednot on this map

A Questionnaire Based Study on Symptoms and Treatment Results in Hereditary Hemorrhagic Telangiectasia (HHT)

TypeobservationalSponsorUniversity Hospital, EssenRan2014 to 2021Enrolled915ConditionsHereditary Haemorrhagic Telangiectasia (HHT)Armsquestionnaire
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Freya DroegeDepartment of Otorhinolaryngology, Head and Neck Surgery, Essen University Hospital, and VASCERN HHT Reference Center, University Duisburg-Essen, Hufelandstrasse 55, Essen, 45122, Germany. Freya.Droege@uk-essen.de.
Kruthika ThangaveluDepartment of Otorhinolaryngology, Head and Neck Surgery, and VASCERN HHT Reference Center, University Hospital Marburg, Philipps-Universität Marburg, Baldingerstrasse, Marburg, 35043, Germany.
Angela KoeningerClinic St. Hedwig of the Order of St. John, Department of Gynecology and Obstetrics, University of Regensburg, Steinmetzstrasse 1-3, Regensburg, 93049, Germany.
Eva Maria HuesslerInstitute for Medical Informatics, Biometry and Epidemiology, Essen University Hospital, University Duisburg-Essen, Hufelandstrasse 55, Essen, 45122, Germany.
Stephan LangDepartment of Otorhinolaryngology, Head and Neck Surgery, Essen University Hospital, and VASCERN HHT Reference Center, University Duisburg-Essen, Hufelandstrasse 55, Essen, 45122, Germany.
Boris A StuckDepartment of Otorhinolaryngology, Head and Neck Surgery, and VASCERN HHT Reference Center, University Hospital Marburg, Philipps-Universität Marburg, Baldingerstrasse, Marburg, 35043, Germany.
Urban W GeisthoffDepartment of Otorhinolaryngology, Head and Neck Surgery, and VASCERN HHT Reference Center, University Hospital Marburg, Philipps-Universität Marburg, Baldingerstrasse, Marburg, 35043, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHereditary Hemorrhagic Telangiectasia (HHT) is a rare vascular disorder with mucocutaneous telangiectasia. Hormones are hypothesized to play a role in reducing bleeding in these patients; however, clear evidence is currently lacking. The aim of this study was to further investigate this hypothesis by assessing the impact of altered hormonal status on HHT severity.

methodsThis cross-sectional electronic questionnaire, available in English and German, was distributed with the support of various self-help groups. It included sections on the general medical history of HHT and the influence of hormones on disease symptoms. Data were collected between March 2016 and August 2017.

resultsOf the 477 respondents with HHT, 326 were female (68%). With increasing age, female patients experienced more severe epistaxis compared to male patients, with a mean age of 54 years (standard deviation ± 11.5 years, range [28,83]). Of the 228 female patients who reported having taken hormones, 73% used them for contraception and 57% for hyper- or dysmenorrhea. Regarding hormone intake, 52% of the patients taking combined estrogen and progestin therapy experienced less epistaxis. Most female patients stated an increase in epistaxis during puberty (41%) and pregnancy (39%), predominantly in the second trimester.

conclusionsIn HHT, variation in levels of hormone concentrations seem to contribute to symptom severity. Off-label use of hormonal products in women with HHT may be considered.

trial registrationClinicaltrials.gov: NCT02690246, Registration Date: 2016–02-09.

Indexed as

EpistaxisTelangiectasia, Hereditary HemorrhagicAdultAgedAged, 80 and overCross-Sectional StudiesEstrogensFemaleHumansMaleMiddle AgedPregnancyProgestinsSeverity of Illness IndexSurveys and QuestionnairesEstrogensProgestinsContraceptivesHereditary hemorrhagic telangiectasia (HHT)Hormonal statusHormone intakePregnancy

Identifiers

PMID41862858
PMCPMC13063478

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.