SynthesisBMC pregnancy and childbirth2026
Parameters of the thrombin generation test in pregnant women with preeclampsia: a systematic review.
Synthesis in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic role of low molecular weight heparin and fat-soluble vitamins in pregnancy-associated prethrombotic conditions.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPreeclampsia (PE) is a major cause of maternal and fetal mortality andmorbidity. Its etiology is idiopathic, but it is known that the disease is associated with a prothrombotic state. In this context, the thrombin generation test (TGT) has been used to investigate hemostatic changes. This systematic review aimed to identify whether the pattern and magnitude of hemostatic changes observed by the TGT differ in PE pregnant women compared to those with normotensive blood pressure and healthy.
methodsThe databases used were PubMed, Lilacs, Web of Science and Embase. The observational studies included at least one TGT parameter. The risk of bias was evaluated using the Newcastle-Ottawa scale and Joanna Briggs Institute (JBI) Quality Appraisal Checklist.
resultsA total of 2,329 articles were retrieved, but only seven were included in the review totaling 850 participants: 290 with PE and 560 normotensive pregnant women. Most studies were considered to be of high quality. In the first trimesters, endogenous thrombin potential (ETP) and peak were significantly higher, while lagtime and time to peak were shorter in pregnant women with PE compared to normotensive women. However, pregnant women with severe PE presented lower ETP and peak, but longer lagtime compared to pregnant women with mild PE. Furthermore, in early onset PE, the activation of coagulation occurs earlier than in late-onset PE.
conclusionThe presence of a state of hypercoagulability in PE is noteworthy, although attenuated in severe cases. According to our data, activation of the coagulation cascade occurs in the early stages of pregnancy, before the clinical manifestation of the disease, which provides an interesting and relevant clinical perspective for TGT.
trial registrationProspero (CRD42023477883).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.