Evidence map›Paper›PMID 41862754›Full record

ArticleNature metabolism2026

DGAT1 mediates sex-specific CD8

Alaa Madi, Hui Shi, Min Su, Ahmed Mady, Boqiong Lv, Haiyan Wang, Bing Yang, Zhenni Yan, Xiaomeng Jin, Lingling Wu and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Overcoming resistance to anti-PD-1/PD-L1 therapy in cancer.Cancer drug resistance (Alhambra, Calif.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Alaa MadiDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany. a.madi@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0003-0744-4360
Hui Shi *State Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Min Su *State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China.
Ahmed MadyData Engineering and Analytics Master program, Technical University of Munich (TUM), Garching, Germany.
Boqiong LvState Key Laboratory of Immune Response and Immunotherapy, School of Basic Medical Sciences, Division of life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Haiyan WangState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Bing YangState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Zhenni YanState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Xiaomeng JinState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Lingling WuState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Mengyue LvState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Marvin HeringDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sicong MaState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Alessa MiegDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2628-9933
Ferdinand ZettlDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2802-3813
Xin YanDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6248-3931
Kerstin MohrDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nora KnabeDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gernot PoschetMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5344-0865
Karsten RichterElectron Microscopy core facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nikolai SchleußnerDivision of Cancer Progression and Metastasis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rene-Filip JackstadtDivision of Cancer Progression and Metastasis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sonja LogesDivision of Personalized Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
F Nina PapavasiliouDivision of Immune Diversity, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5971-7909
Xi WangState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. xiwang@njmu.edu.cn.ORCID http://orcid.org/0000-0002-7572-6354
Jingxia WuState Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China. jingxia.wu@ihm.ac.cn.ORCID http://orcid.org/0009-0001-2559-0065
Guoliang CuiDivision of T Cell Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany. gcui@ustc.edu.cn.ORCID http://orcid.org/0000-0001-5559-7957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid (FA) oxidation plays an important role in T cell responses. However, whether DGAT1-mediated FA esterification to triacylglycerol also regulates T cell function remains unclear. Here we uncover a sexually dimorphic requirement for DGAT1 expression in CD8

Indexed as

CD8-Positive T-LymphocytesDiacylglycerol O-AcyltransferaseAnimalsEndoplasmic Reticulum StressFatty AcidsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, AndrogenSignal TransductionT-Cell ExhaustionDgat1 protein, mouseDiacylglycerol O-AcyltransferaseFatty AcidsReceptors, Androgen

Identifiers

PMID41862754

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.