ArticleNature genetics2026
A pangenome reference and population studies link structural variants with breeding traits in Gossypium hirsutum.
Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Cotton Salt Stress Resilience: Integrating Physiological, Molecular, and Agronomic Strategies for Next-Generation Breeding.Plant, cell & environment · 2026Review
- Article
- Cotton genetic mapping for plant biotechnology: from markers to graph pan-genomes and sustainable breeding.Frontiers in plant science · 2026Review
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Authors and funding
38 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limited pangenome and ambiguous genomic architecture constrain comprehensive genetic variation discovery and cotton improvement. Here we assembled a telomere-to-telomere (T2T) genome for elite cultivar NDM13 and near-T2T genomes for 27 additional representatives of Gossypium hirsutum over the recent century, with transcriptomic profiling of 15 distinct tissues from each. We uncovered 51,551 one-to-one conserved orthologs across all genomes and landscapes of telomere, centromere, 45S rDNA, segmental duplication and copy number variant. We revealed hotspots of structural variation (SV) and impacts of SV, segmental duplication and copy number variant on gene expression or content alteration, as well as adversity resistances. We identified thousands of divergent SVs and genes implicated in modern breeding evolution. Combining T2T-reference-based pangenome construction and 761,536 SVs identified across 1,671 worldwide accessions with phenotypic data from 22 environments, we captured a number of hidden SVs that potentially influence critical breeding traits. These will boost genetic study and biotechnological improvement of the crop.
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