ArticleNature immunology2026
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size.
Abstract read
In one paragraph
Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- SMAD4-BPIFA1 Axis Governs Airway Antiviral Defense in Myhre Syndrome.Biomolecules · 2026Article
- Early immune responses anticipate HIV rebound and precede viral control.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
33 authors.
Khader Ghneim *Pathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Felipe Ten-Caten *Pathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7771-1490
Ana Carolina SantanaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Muhammad Bilal LatifPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Diego Andres Diaz-DinamarcaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-5677-920X
Tamara García-SalumPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Perla Mariana Del Rio EstradaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-3366-3268
Puja SohalPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0009-0001-2147-5211
Zachary StronginDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Justin HarperDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6948-3501
Sherrie JeanDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Chelsea WallaceDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, USA.
Robert BalderasBecton Dickinson, San Jose, CA, USA.ORCID http://orcid.org/0000-0002-8734-8629
Jeffrey D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Gopalan RaghunathanDepartment of Discovery Biologics, Merck & Co., South San Francisco, CA, USA.
Eric RimmerDepartment of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., South San Francisco, CA, USA.
Cinthia V PastuskovasDepartment of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., South San Francisco, CA, USA.
Guoxin WuDepartment of Quantitative Biosciences, Merck & Co., Rahway, NJ, USA.
Luca MicciDepartment of Discovery Oncology, Merck & Co., Boston, MA, USA.
Luiz Felipe Martins SiebenDepartment of Mathematics, Cleveland State University, Cleveland, OH, USA.
Pedro Cesar Lopes GerumDepartment of Mathematics, Cleveland State University, Cleveland, OH, USA.
Jessica Dos SantosDepartment of Internal Medicine, Radboudumc, Nijmegen, The Netherlands.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-2421-6052
Andre van der VenDepartment of Internal Medicine, Radboudumc, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-1833-3391
Guido SilvestriPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-6602-2470
Daria J HazudaDepartment of Quantitative Biosciences, Merck & Co., Rahway, NJ, USA.
Daniel M GormanDepartment of Discovery Biologics, Merck & Co., South San Francisco, CA, USA.
Bonnie J HowellDepartment of Quantitative Biosciences, Merck & Co., Rahway, NJ, USA.
Ashish A SharmaPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9444-7046
Mirko PaiardiniPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7276-3600
Hugo SoudeynsPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Susan Pereira RibeiroPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. susan.pereira.ribeiro@emory.edu.ORCID http://orcid.org/0000-0002-3127-3138
Rafick P SekalyPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. rafick.sekaly@emory.edu.ORCID http://orcid.org/0000-0002-7816-4828
Funding
Reversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0MHarnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIVR37AI141258 · NIAID · EMORY UNIVERSITY · PI Rafick Pierre Sekaly · 2018 to 2026
$7.8MMultiOMICS to uncover immune and virological mechanisms that drive HIV DNA decay, restore immune homeostasis, and promote HIV specific immunity in PWH receiving cell therapies.P01AI178376 · NIAID · EMORY UNIVERSITY · PI Rafick Pierre Sekaly · 2023 to 2026
$6.1MDefining molecular pathways triggered by IL-10 and TGFb that drive HIV integration and persistence in Tfh cells in lymph nodesR01AI179476 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Susan Pereira Ribeiro · 2023 to 2026
$2.7MNIAID NIH HHS R01 AI179476U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01AI178376U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI179476U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R37AI141258U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) UM1AI164561
Abstract
Immune interventions toward an HIV cure have focused on rejuvenating adaptive immune responses. Herein we provide a framework that features epigenetic programming of myeloid and CD4
Indexed as
Epigenesis, GeneticImmunity, InnateSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTransforming Growth Factor betaAnimalsCD4-Positive T-LymphocytesDNA, ViralHistone Deacetylase InhibitorsHumansInterferon Regulatory FactorsMacaca mulattaSignal TransductionDNA, ViralHistone Deacetylase InhibitorsInterferon Regulatory FactorsTransforming Growth Factor beta
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.